The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel

Dattananda S ChelurMartin Chalfie


Mechanosensory transduction in touch receptor neurons is believed to be mediated by DEG/ENaC (degenerin/epithelial Na+ channel) proteins in nematodes and mammals. In the nematode Caenorhabditis elegans, gain-of-function mutations in the degenerin genes mec-4 and mec-10 (denoted mec-4(d) and mec-10(d), respectively) cause degeneration of the touch cells. This phenotype is completely suppressed by mutation in a third gene, mec-6 (refs 3, 4), that is needed for touch sensitivity. This last gene is also required for the function of other degenerins. Here we show that mec-6 encodes a single-pass membrane-spanning protein with limited similarity to paraoxonases, which are implicated in human coronary heart disease. This gene is expressed in muscle cells and in many neurons, including the six touch receptor neurons. MEC-6 increases amiloride-sensitive Na+ currents produced by MEC-4(d)/MEC-10(d) by approximately 30-fold, and functions synergistically with MEC-2 (a stomatin-like protein that regulates MEC-4(d)/MEC-10(d) channel activity) to increase the currents by 200-fold. MEC-6 physically interacts with all three channel proteins. In vivo, MEC-6 co-localizes with MEC-4, and is required for punctate MEC-4 expression along touch-neuron...Continue Reading


Nov 18, 2008·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Stephan Frings
Feb 8, 2007·Pflügers Archiv : European journal of physiology·Alexander Bounoutas, Martin Chalfie
Apr 29, 2009·Biochemistry·Comert KuralPaul R Selvin
Aug 2, 2008·Cell Death and Differentiation·W ZhangMonica Driscoll
Dec 15, 2006·Nature·Christiane WetzelGary R Lewin
Jun 1, 2010·Nature Neuroscience·Marios ChatzigeorgiouWilliam R Schafer
Dec 29, 2004·Nature Neuroscience·Diane Ronan, Peter Gillespie
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Martin Chalfie
Apr 21, 2004·Nature Structural & Molecular Biology·Michal HarelDan S Tawfik
Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tinsley Davis
Jun 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Martin Chalfie
May 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chun-Liang PanSteven McIntire
Nov 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Irini Topalidou, Martin Chalfie
Oct 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xin GengDing Xue
Mar 3, 2010·Annual Review of Biophysics·Jóhanna Arnadóttir, Martin Chalfie
Oct 1, 2010·Journal of Neurophysiology·Marios ChatzigeorgiouWilliam R Schafer
Jul 25, 2012·Lipids in Health and Disease·Ayman Samir Farid, Yoichiro Horii
Apr 9, 2005·Molecular Pain·Liam J Drew, John N Wood
Mar 3, 2010·PloS One·Yehuda Ben-ShaharMichael J Welsh
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lu HanLaura Bianchi
Sep 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jóhanna ArnadóttirMartin Chalfie
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Miriam B Goodman
May 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Xin-Liang ZhouYoshiro Saimi
Nov 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tobias B HuberThomas Benzing
Nov 18, 2008·Journal of Neurogenetics·Evan L Ardiel, Catharine H Rankin
Oct 20, 2010·The Journal of Cell Biology·Ellen A LumpkinAislyn M Nelson
Dec 3, 2014·Current Biology : CB·Stephanie E MauthnerW Daniel Tracey
Sep 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yushu ChenMartin Chalfie
Nov 26, 2010·Science China. Life Sciences·Hui YangDaFang Huang
Dec 12, 2013·Journal of Molecular Signaling·Chun-Hao ChenChun-Liang Pan
Sep 14, 2004·Journal of Neurobiology·David M Tobin, Cornelia I Bargmann
Sep 14, 2004·Journal of Neurobiology·Gary R Lewin, Rabih Moshourab
Jul 2, 2009·Angewandte Chemie·Martin Chalfie
Mar 16, 2013·Journal of Cellular and Molecular Medicine·Chih-Cheng Chen, Chia-Wen Wong


Apr 1, 1995·Current Biology : CB·J García-AñoverosMartin Chalfie
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·G GuMartin Chalfie
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·S HarbinderMonica Driscoll
Dec 16, 1998·Science·C. elegans Sequencing Consortium
May 25, 1999·BioTechniques·D M MillerA Fire
Apr 17, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·P N DurringtonM I Mackness
Aug 30, 2001·Cell·F GalbiatiM P Lisanti
Mar 5, 2002·Nature·Miriam B GoodmanMartin Chalfie
Aug 9, 2002·The Journal of Biological Chemistry·Warren G HillJohn P Johnson
Nov 14, 2002·Annual Review of Genetics·Glen G Ernstrom, Martin Chalfie

Related Concepts

Calcinus elegans
Cyartonema elegans
Channel Activity
Coleonyx elegans
MEC-10 protein, C elegans
Degenerin Sodium Channels
Abnormal Degeneration
Meissner's Corpuscle
Cestrum elegans
Clarkia unguiculata

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.