The "mechanostat" principle in cell differentiation. The osteochondroprogenitor paradigm

Journal of Cellular Biochemistry
Joanna B Tyrovola

Abstract

The "mechanostat" principle may be depicted as an oscillating signal of a signaling molecule, in which the amplitude, frequency, cumulative level, delay, and duration of the curve encode the information for concrete cellular responses and biological activities. When the oscillating signal is kept sustained (present delay), cell exit may be performed, whereas when the oscillating signal remains robust, cell proliferation may take place. B-catenin-Wnt signaling pathway has a key role in the differentiation of osteochondroprogenitor cells. Sustained downregulation of the β-catenin-Wnt pathway forces osteochondroprogenitors to a chondrogenic fate instead of an osteoblastic one. Other signaling, for example, bone morphogenetic protein and Notch signaling pathways interact with the Wnt pathway. The crosstalk between biochemical and mechanical stimuli produces the final information that leads to the final cell fate decisions, through the "mechanostat" principle.

References

Feb 5, 2000·Nature·N Barkai, S Leibler
Apr 26, 2001·Journal of Theoretical Biology·C Furusawa, K Kaneko
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·José M G VilarStanislas Leibler
Dec 6, 2002·Journal of Biological Rhythms·Gen Kurosawa, Yoh Iwasa
Mar 22, 2003·Current Opinion in Cell Biology·John J TysonBela Novak
Aug 7, 2003·Trends in Genetics : TIG·Kazuhisa Nakashima, Benoit de Crombrugghe
Mar 22, 2005·Journal of Cellular Biochemistry·Kaihong Mi, Gail V W Johnson
Apr 2, 2005·The Journal of Biological Chemistry·Sheri L HolmenBart O Williams
May 4, 2005·Developmental Cell·Donald A GlassGerard Karsenty
Jun 9, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Julie R HensJohn J Wysolmerski
Jun 20, 2006·Current Topics in Developmental Biology·Donald A Glass, Gerard Karsenty
Aug 16, 2006·The Journal of Biological Chemistry·John A RobinsonFrederick J Bex
Feb 10, 2007·Nature Medicine·Steven R Goldring, Mary B Goldring
May 19, 2007·Nature Reviews. Genetics·Uri Alon
Aug 7, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Isha JainM Kathryn Iovine
Dec 20, 2007·The Journal of Biological Chemistry·Alexander G RoblingCharles H Turner
Feb 19, 2008·Bone·Lynda F Bonewald, Mark L Johnson
Mar 12, 2008·Archives of Biochemistry and Biophysics·Pierre J Marie
Apr 11, 2008·Neuron·Hiromi ShimojoRyoichiro Kageyama
Sep 5, 2008·Annual Review of Genomics and Human Genetics·Gerard Karsenty
Oct 31, 2008·Nature Reviews. Molecular Cell Biology·Béla Novák, John J Tyson
Dec 25, 2008·Journal of Oral Science·Joanna B TyrovolaDespoina Perrea
Jan 28, 2009·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Mari M SatoMasato Tamura
May 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chuwen LinLin He
Jun 30, 2009·Nucleic Acids Research·Caroline C FriedelRalf Zimmer
Jun 1, 2010·Journal of Cellular Biochemistry·Natasha Case, Janet Rubin
Jul 20, 2010·Current Biology : CB·Leah HerrgenAndrew C Oates
Oct 20, 2010·Current Opinion in Genetics & Development·Marcelo Behar, Alexander Hoffmann
Feb 18, 2011·Journal of Cellular Biochemistry·Toshihisa Komori
Mar 19, 2011·Cell·James E FerrellQiong Yang
Apr 8, 2011·Journal of Pineal Research·Ki-Ho ParkSung Hoon Kim
Jul 28, 2011·Journal of Cellular Biochemistry·Grace L Lin, Kurt D Hankenson
Dec 22, 2011·Journal of Theoretical Biology·Hiroshi KoriNaoki Masuda
Feb 1, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C ZuoX Zhang
Apr 10, 2012·Annual Review of Neuroscience·Jennifer A MohawkJoseph S Takahashi

❮ Previous
Next ❯

Citations

Jun 26, 2020·Frontiers in Physiology·Beatriz Carmona FerreiraAna Cláudia Rossi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.