PMID: 9420330Feb 21, 1998Paper

The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain

Genes & Development
L C MyersRoger D Kornberg

Abstract

Mediator was resolved from yeast as a multiprotein complex on the basis of its requirement for transcriptional activation in a fully defined system. Three groups of mediator polypeptides could be distinguished: the products of five SRB genes, identified as suppressors of carboxy-terminal domain (CTD)-truncation mutants; products of four genes identified as global repressors; and six members of a new protein family, termed Med, thought to be primarily responsible for transcriptional activation. Notably absent from the purified mediator were Srbs 8, 9, 10, and 11, as well as members of the SWI/SNF complex. The CTD was required for function of mediator in vitro, in keeping with previous indications of involvement of the CTD in transcriptional activation in vivo. Evidence for human homologs of several mediator proteins, including Med7, points to similar mechanisms in higher cells.

References

Feb 24, 1989·Cell·B J Thomas, R Rothstein
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W R Pearson, D J Lipman
Jan 1, 1987·Methods in Enzymology·J D BoekeG R Fink
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y LiR D Kornberg
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·C M Thompson, R A Young
Dec 1, 1994·Protein Science : a Publication of the Protein Society·H Erdjument-BromageP Tempst
Apr 15, 1995·Genes & Development·C J HengartnerR A Young
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·B R CairnsR D Kornberg
Mar 31, 1994·Nature·A J Koleske, R A Young
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y Li, R D Kornberg
Sep 12, 1996·Nature·S S WalkerM R Green
Jan 1, 1996·Methods in Enzymology·Y LiR D Kornberg
Jan 1, 1996·Annual Review of Biochemistry·S K Burley, R G Roeder
Jan 3, 1997·The Journal of Biological Chemistry·C M GustafssonR D Kornberg
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·J Q SvejstrupR D Kornberg

❮ Previous
Next ❯

Citations

Jun 8, 2000·Journal of Cellular Biochemistry·C L Peterson, C Logie
Feb 4, 2005·Chromosoma·Erik BlazekMichael Meisterernst
Jun 8, 2006·Molecular Genetics and Genomics : MGG·Magnus HallbergHans Ronne
May 15, 2002·FEMS Microbiology Reviews·Fernando Moreno, Pilar Herrero
Jul 25, 2000·Trends in Genetics : TIG·P Sudarsanam, F Winston
May 10, 2001·Current Opinion in Cell Biology·C Rachez, L P Freedman
Jul 8, 1999·Current Opinion in Cell Biology·A J Berk
Apr 8, 2000·Current Opinion in Genetics & Development·C L Peterson, J L Workman
Oct 31, 1998·Current Opinion in Genetics & Development·J D Parvin, R A Young
Dec 28, 1999·Trends in Cell Biology·R D Kornberg
Jun 6, 2000·Trends in Biochemical Sciences·N Proudfoot
Jun 6, 2000·Trends in Biochemical Sciences·S Malik, R G Roeder
Jun 11, 2002·Methods : a Companion to Methods in Enzymology·G Sebastiaan WinklerPaul Tempst
Jul 11, 2013·Chemical Reviews·Célia JeronimoFrançois Robert
Nov 6, 2012·Nature·Laurent LarivièrePatrick Cramer
Mar 4, 2003·Nature Reviews. Molecular Cell Biology·Masafumi Muratani, William P Tansey
Apr 9, 2013·Nature Structural & Molecular Biology·Kuang-Lei TsaiFrancisco J Asturias
Jul 17, 2001·Molecular Microbiology·C M Gustafsson, T Samuelsson
Oct 24, 2002·European Journal of Biochemistry·Linda HollandKrassimir Yankulov
Jan 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·D BarillàN J Proudfoot
Jul 14, 2010·The Journal of Biological Chemistry·Olga KhorosjutinaClaes M Gustafsson
Aug 13, 2011·The Journal of Biological Chemistry·Sapan BorahRupinder Kaur
May 19, 2012·The Journal of Biological Chemistry·Stella M RanuncoloBrian A Lewis
Oct 28, 2005·Molecular Biology of the Cell·Sonja ReinerRoger Schneiter
Jul 30, 2002·The EMBO Journal·Nicolas BischlerPatrick Schultz
Sep 29, 1999·Genes & Development·N YudkovskyC L Peterson
Jan 30, 1999·Genes & Development·C BatchelderT K Blackwell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.