The medial amygdala modulates body weight but not neuroendocrine responses to chronic stress

Journal of Neuroendocrinology
M B SolomonJ P Herman

Abstract

Stress pathologies such as depression and eating disorders (i.e. anorexia nervosa) are associated with amygdalar dysfunction, which are linked with hypothalamic-pituitary-adrenal axis (HPA) axis hyperactivity. The medial amygdaloid nucleus (MeA), a key output nucleus of the amygdaloid complex, promotes HPA axis activation to acute psychogenic stress and is in a prime position to mediate the deleterious effects of chronic stress on physiology and behaviour. The present study tests the hypothesis that the MeA is necessary for the development of maladaptive physiological changes caused by prolonged stress exposure. Male rats received bilateral ibotenate or sham lesions targeting the MeA and one half underwent 2 weeks of chronic variable stress (CVS) or served as home cage controls. Sixteen hours post CVS, all animals were exposed to an acute restraint challenge. CVS induced thymic involution, adrenal hypertrophy, and attenuated body weight gain and up-regulation of hypothalamic corticotrophin-releasing hormone mRNA expression. Consistent with previous literature, lesions of the MeA dampened stress-induced increases in corticosterone after 30 min of exposure to acute restraint stress. However, this effect was independent of CVS exp...Continue Reading

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Citations

Feb 4, 2012·Cellular and Molecular Neurobiology·Brent MyersJames P Herman
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·David CrewsMichael K Skinner
May 5, 2011·American Journal of Physiology. Endocrinology and Metabolism·Matia B SolomonMichelle T Foster
Nov 26, 2010·Endocrinology·Ryan JankordJames P Herman
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric G KrauseRandall R Sakai
Dec 24, 2013·Frontiers in Neuroendocrinology·Brent MyersJames P Herman
Jul 2, 2011·Behavioural Brain Research·Amy R FurayJohn F Neumaier
Oct 12, 2010·Physiology & Behavior·Matia B SolomonJames P Herman
Mar 2, 2016·Nature Reviews. Urology·Liana MerrillMargaret A Vizzard
Aug 2, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Antonio AbellánLoreta Medina
Feb 26, 2015·Physiology & Behavior·Abigail K ThompsonYvonne M Ulrich-Lai
Oct 6, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Devon L GrahamMichael T Williams
Aug 8, 2015·Brain Structure & Function·Yvonne M Ulrich-LaiJames P Herman
Apr 18, 2013·Brain Research Bulletin·Nadezhda Bazhan, Dóra Zelena
Jan 29, 2017·Physiology & Behavior·Susan J MelhornRandall R Sakai
May 10, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liana MerrillMargaret A Vizzard
Jun 12, 2019·Stress : the International Journal on the Biology of Stress·Aki T-B ChaffinKaren K Ryan
Mar 31, 2016·Journal of Neuroendocrinology·M H HuK T O'Byrne
Nov 16, 2016·Frontiers in Endocrinology·James P Herman, Jeffrey G Tasker
Dec 17, 2019·Journal of the American Heart Association·Derek SchaeubleBrent Myers
Nov 5, 2019·Frontiers in Physiology·Kristy L JacksonFrancine Z Marques
Aug 14, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiro ShimizuMotoaki Saito

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