The medial prefrontal cortex: coordinator of autonomic, neuroendocrine and behavioural responses to stress.

Journal of Neuroendocrinology
J M McKlveenJ P Herman

Abstract

Responding to real or potential threats in the environment requires the coordination of autonomic, neuroendocrine and behavioural processes to promote adaptation and survival. These diverging systems necessitate input from the limbic forebrain to integrate and modulate functional output in accordance with contextual demand. In the present review, we discuss the potential role of the medial prefrontal cortex (mPFC) as a coordinator of behavioural and physiological stress responses across multiple temporal and contextual domains. Furthermore, we highlight converging evidence from rodent and human research indicating the necessity of the mPFC for modulating physiological energetic systems to mobilise or limit energetic resources as needed to ultimately promote behavioural adaptation in the face of stress. We review the literature indicating that glucocorticoids act as one of the primary messengers in the reallocation of energetic resources having profound effects locally within the mPFC, as well as shaping how the mPFC acts within a network of brain structures to modulate responses to stress. Finally, we discuss how both rodent and human studies point toward a critical role of the mPFC in the coordination of anticipatory responses...Continue Reading

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Citations

Oct 22, 2016·Biological Psychiatry·Jessica M McKlveenJames P Herman
Apr 20, 2016·Scientific Reports·Ting-Hsuan WuJen-Chuen Hsieh
Sep 1, 2016·Behavioural Brain Research·Joshua D CroteauJack D Shepard
Oct 30, 2016·Physiology & Behavior·Brent Myers
May 26, 2017·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Megan R Gunnar
Feb 6, 2017·Frontiers in Psychology·Bruno Kluwe-SchiavonRodrigo Grassi-Oliveira
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Dec 24, 2018·Journal of Neuroendocrinology·Edo R de KloetAnnette D de Kloet
Feb 21, 2019·Journal of Neuroendocrinology·Tatsushi Onaka, Yuki Takayanagi
May 29, 2019·Stress : the International Journal on the Biology of Stress·W Tang WatanasriyakulAngela J Grippo
Nov 4, 2017·Biology of Sex Differences·Alex G LeeDavid M Lyons
Jan 11, 2018·Stress : the International Journal on the Biology of Stress·Ankit SoodVidita A Vaidya
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Jul 2, 2020·Neuropsychiatric Disease and Treatment·Shuhua RanHaitao Li
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Sep 24, 2019·Frontiers in Human Neuroscience·Joseph K NuamahSeok Chang Ryu
Sep 10, 2018·Brain Structure & Function·Anne NosjeanSylvie Granon

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