The medial temporal lobe in dementia with Lewy bodies: a comparative study with Alzheimer's disease

Annals of Neurology
Carol LippaT W Smith

Abstract

The usefulness of determining medial temporal lobe (MTL) size in differentiating Alzheimer's disease (AD) from other dementia subtypes is unknown. We compared the cross-sectional areas of the MTLs in histological sections from the brains of 18 patients with dementia with Lewy bodies (DLB) but lacking AD changes, 24 DLB patients with concurrent AD pathology, 20 pure AD cases, and 18 age-matched control cases. Duration and severity of disease were comparable between groups. When data for cross-sectional area were expressed as percentages of the average control area, DLB MTLs were significantly larger than either AD or DLB/AD MTLs at rostral levels (86 +/- 16%, 54 +/- 17%, and 66 +/- 23% of control areas, respectively). At caudal levels, DLB MTLs were larger than AD MTLs (80 +/- 20%, 59 +/- 21%, and 77 +/- 26% of control areas in DLB, AD, and DLB/AD, respectively). MTL cross-sectional area often approaches normal in pure DLB, even when disease duration is prolonged and symptoms are end stage. In contrast, a greatly reduced MTL area mitigates against the diagnosis of DLB, unless there are concurrent AD changes.

References

Jan 1, 1991·Hippocampus·G W Van HoesenA R Damasio
Oct 1, 1990·Neurology·H A CrystalL I Wolfson
Jun 1, 1990·Journal of Neurology·K Kosaka
Oct 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J P SeabT F Budinger
Oct 1, 1986·Annals of Neurology·B T HymanA R Damasio
Mar 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·H FörstlR Levy
Apr 15, 1997·Journal of the Neurological Sciences·C F LippaT W Smith

❮ Previous
Next ❯

Citations

Dec 1, 2011·International Psychogeriatrics·Rosie WatsonAndrew M Blamire
Aug 26, 2004·Journal of the International Neuropsychological Society : JINS·Joanne M HamiltonLeon J Thal
Feb 3, 2007·Brain : a Journal of Neurology·Jennifer L WhitwellClifford R Jack
Sep 27, 2003·Alzheimer Disease and Associated Disorders·Monika AtiyaRonald Killiany
Aug 2, 2008·Clinical Neuropharmacology·Francesca AnzellottiMarco Onofrj
Jul 12, 2008·Annual Review of Psychology·David P Salmon, Mark W Bondi
Sep 22, 2005·Dementia and Geriatric Cognitive Disorders·Teresa BuracchioMartin Gorbien
Sep 21, 2001·Journal of Geriatric Psychiatry and Neurology·Y Y HsuM W Weiner
Feb 2, 2012·The Primary Care Companion to CNS Disorders·Melanie ZupancicKamna Handa
Mar 10, 2001·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·H ChertkowA M Clarfield
Jul 17, 2004·Neuroreport·Christian BrenneisWerner Poewe
Apr 17, 2001·Neuropathology : Official Journal of the Japanese Society of Neuropathology·R A ArmstrongP L Lantos
Jun 20, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Richard CamicioliJeffrey A Kaye
Mar 13, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Xiaqing XuanXiangyang Gong
Dec 13, 2000·International Journal of Geriatric Psychiatry·T Del SerR Spiegel
Aug 15, 2003·The Cochrane Database of Systematic Reviews·R WildA Burns
Dec 16, 1998·Current Opinion in Neurology·F Pasquier, A Delacourte

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.