The mediating effects of gestational diabetes on fetal growth and adiposity in women who are overweight and obese: secondary analysis of the LIMIT randomised trial

BJOG : an International Journal of Obstetrics and Gynaecology
A J PoprzecznyJ M Dodd

Abstract

To describe the mediating effect of maternal gestational diabetes on fetal biometry and adiposity measures among overweight or obese pregnant women. Secondary analysis of the LIMIT randomised trial. Public hospitals, metropolitan Adelaide, South Australia. Pregnant women with body mass index (BMI) ≥25 kg/m2 and singleton gestation. Fetal ultrasound measures at 36 weeks of gestation and baseline BMI from women randomised to the LIMIT trial Standard Care group (n = 912 women) were used to conduct causal mediation analyses using regression-based methods. Ultrasound measures of fetal biometry and adiposity at 36 weeks of gestation. Increased maternal BMI was associated with increased measures of fetal head circumference [direct (unmediated) effect 0.18 (95% CI: 0.05-0.31), P = 0.005; total effect 0.17 (95% CI: 0.02-0.31), P = 0.018], abdominal circumference [direct effect 0.26 (95% CI: 0.11-0.41), P = 0.001; total effect 0.26 (95% CI: 0.11-0.42), P = 0.001] and estimated fetal weight [direct effect 0.22 (95% CI: 0.08-0.35), P = 0.002; total effect 0.22 (95% CI: 0.08-0.35), P = 0.002], with no evidence of mediation by treated gestational diabetes. There was no apparent association between maternal BMI and fetal adiposity measures, o...Continue Reading

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Citations

Apr 17, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·Y AkibaM Tanaka
Jun 20, 2020·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Joana Sousa NunesJosé Manuel Furtado
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