The Mediator complex subunit 8 regulates organ size in Arabidopsis thaliana.

Plant Signaling & Behavior
Ran Xu, Yunhai Li

Abstract

Control of final organ size is a fundamental and core process of development of all multicellular organisms, but the mechanisms that set the final size of determinate organs are largely unknown. In a recent study, we demonstrated that the Mediator complex subunit 25 (MED25/PFT1), which is involved in the transcriptional regulation of gene expression, controls the final size of determinate organs by restricting both cell proliferation and cell expansion. med25 mutants formed large organs with larger and slightly more cells, whereas plants overexpressing MED25 produced small organs due to a reduction in both cell number and cell size. Here, we show that a loss-of-function mutation in the Mediator complex subunit 8 (MED8) causes small flowers as a result of reduced cell expansion. Analysis of the med8 med25-2 double mutant reveals that MED8 acts independently of MED25 to regulate cell expansion and organ growth. Taken together, our findings show that MED8 and MED25 play an important role in regulating organ size. Further identification of upstream and downstream components of MED8 and MED25 will help understand how the Mediator complex is involved in organ size control in plants.

References

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Jun 15, 2007·Molecular Cell·Stefan BäckströmStefan Björklund
May 17, 2008·Genes & Development·Yunhai LiMichael W Bevan
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Citations

Oct 23, 2013·AoB Plants·Victor E Balderas-HernándezSaúl Fraire-Velázquez
Feb 14, 2013·Journal of Experimental Botany·Beth A Krizek, Jill T Anderson
Jul 15, 2015·Journal of Integrative Plant Biology·Yan YangLi-Jia Qu
Jan 25, 2014·The Plant Journal : for Cell and Molecular Biology·Yan YangLi-Jia Qu
Oct 7, 2015·Frontiers in Plant Science·Subhasis Samanta, Jitendra K Thakur
Feb 11, 2014·Current Opinion in Plant Biology·Jo Hepworth, Michael Lenhard
May 25, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jun ItoMasahiko Furutani
Jun 12, 2016·Developmental Biology·Manuel Buendía-Monreal, C Stewart Gillmor
May 20, 2017·Critical Reviews in Biochemistry and Molecular Biology·Naveen MalikAkhilesh Tyagi
Nov 9, 2019·The Plant Journal : for Cell and Molecular Biology·Naveen MalikAkhilesh K Tyagi
Jul 1, 2017·Frontiers in Plant Science·Kemal Kazan

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