Sep 1, 1976

The mediator of cellular immunity. XII. Inhibition of activated T cells by Newcastle disease virus

The Journal of Experimental Medicine
D D McGregorL E Carmichael


Newcastle disease virus (NDV) can interact in at least two ways with rat T cells. By adsorbing to circulating lymphocytes, the virus can transiently deflect the cells from lymph nodes and inflammatory exudates induced in the peritoneal cavity. T cells are affected regardless of age, state of activation, or position in the mitotic cycle. The effect is reversible and is mediated not only by infectious (I)-NDV, but also by UV-NDV which cannot achieve a complete replication cycle in eggs. But I-NDV has another lasting effect on activated T cells. It is revealed in the failure of virus-treated thoracic duct lymphocytes to transfer cellular resistance to Listeria monocytogenes, delayed-type hypersensitivity to soluble antigens of the parasite, and the permanent exclusion of labeled S-phase lymphocytes from inflammatory foci. Activated T cells are inhibited by virus multiplicites which have little if any effect upon the proliferative potential of antigen-sensitive T cells or localization of labeled small lymphocytes in lymph nodes. The underlying mechanism has not been determined; however, there are reasons for thinking that NDV has a lethal effect upon activated T cells, because the latter are permissive for virus replication.

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Mentioned in this Paper

Establishment and Maintenance of Localization
Newcastle disease virus
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Virus Replication
Graft Vs Host Reaction
Entire Peritoneal Cavity
Listeria monocytogenes

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