The medical treatment of cicatricial alopecia

Seminars in Cutaneous Medicine and Surgery
Vera H Price

Abstract

The best outcome of current treatments of cicatricial alopecia is induction of a clinical remission with arrest of symptoms and signs, but the progression of hair loss may continue insidiously. Current treatments do not arrest the underlying disease process. A scalp biopsy is the first step in management. Selection of treatment described herein is guided by the histopathologic findings, including the type, location and extent of the predominant cellular inflammatory infiltrate, and clinical disease activity. Cicatricial alopecias with predominantly lymphocytic infiltrates are treated with immunomodulating agents, and those with predominantly neutrophilic infiltrates are treated with antimicrobial agents. Treatment selection may be challenging and requires flexibility, as histopathologic features frequently overlap, are not clear cut, or change over time. In the future, cellular and molecular biology studies will hopefully identify unique markers for the clinically distinct cicatricial alopecias and lead to better treatments and a cure.

References

Jan 1, 1990·Journal of the American Academy of Dermatology·V C HoJ J Voorhees
Feb 22, 1997·Lancet·M BöhmT Luger
Sep 17, 1998·Journal of the American Academy of Dermatology·M LebwohlG Weinstein
Jul 5, 2001·Journal of Cutaneous Pathology·L C Sperling
Jan 11, 2003·Journal of the American Academy of Dermatology·Elise A OlsenUNKNOWN Workshop on Cicatricial Alopecia
Sep 27, 2003·Journal of the American Academy of Dermatology·Paradi MirmiraniVera H Price
Nov 26, 2003·Journal of the American Academy of Dermatology·Uta FrielingStefan Beissert
Mar 29, 2005·Journal of the American Academy of Dermatology·Paradi MirmiraniVera H Price
Jun 21, 2005·Journal of the American Academy of Dermatology·Elizabeth K RossJerry Shapiro
Sep 29, 2005·International Journal of Dermatology·R Mzudumile Ngwanya

❮ Previous
Next ❯

Citations

Dec 23, 2009·Archives of Dermatology·Paradi Mirmirani, Pratima Karnik
Apr 1, 2014·Dermatologic Clinics·Temitayo A OgunleyeElise A Olsen
Jan 12, 2010·Journal of the American Academy of Dermatology·Bryan K ChoVera H Price
Jul 18, 2009·Seminars in Cutaneous Medicine and Surgery·Jennifer M Fu, Vera H Price
Mar 19, 2009·Journal of the American Academy of Dermatology·Raechele Cochran Gathers, Henry W Lim
Dec 5, 2008·The Journal of Investigative Dermatology·Pratima KarnikParadi Mirmirani
Aug 22, 2008·Dermatologic Therapy·Abdullateef A AlzolibaniJerry Shapiro
Aug 22, 2008·Dermatologic Therapy·Hoon KangJerry Shapiro
May 21, 2008·The British Journal of Dermatology·M J HarriesR Paus
Jun 1, 2021·Dermatologic Clinics·Maria Hordinsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Dermatologic Therapy
Najwa Somani, Wilma F Bergfeld
Actas dermo-sifiliográficas
L Abal-DíazJ M Casanova-Seuma
© 2022 Meta ULC. All rights reserved