The Medicinal Chemistry of Dengue Virus

Journal of Medicinal Chemistry
Mira A M BehnamChristian D Klein

Abstract

The dengue virus and related flaviviruses are an increasing global health threat. In this perspective, we comment on and review medicinal chemistry efforts aimed at the prevention or treatment of dengue infections. We include target-based approaches aimed at viral or host factors and results from phenotypic screenings in cellular assay systems for viral replication. This perspective is limited to the discussion of results that provide explicit chemistry or structure-activity relationship (SAR), or appear to be of particular interest to the medicinal chemist for other reasons. The discovery and development efforts discussed here may at least partially be extrapolated toward other emerging flaviviral infections, such as West Nile virus. Therefore, this perspective, although not aimed at flaviviruses in general, should also be able to provide an overview of the medicinal chemistry of these closely related infectious agents.

References

May 25, 1989·Nucleic Acids Research·A E GorbalenyaV M Blinov
Mar 22, 2002·Journal of Virology·Shu-Fen WuYi-Ling Lin
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eric C M van GorpJos W M van Der Meer
May 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yorgo ModisStephen C Harrison
Jan 1, 1956·The Journal of Infectious Diseases·S HOTTA, C A EVANS
Dec 24, 2003·Advances in Virus Research·Scott B Halstead
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lixin MaCarol Beth Post
Oct 27, 2004·The Journal of Biological Chemistry·Andrew L LoveringNatalie C J Strynadka
Mar 23, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·I HavlikY Kaneko
Apr 13, 2005·Biochemical and Biophysical Research Communications·Santad ChanprapaphGerd Katzenmeier
Jun 2, 2005·Virology Journal·Yancey M HrobowskiScott F Michael
Jun 16, 2005·Journal of Virology·Jorge L Muñoz-JordánAdolfo García-Sastre
Jul 5, 2005·Journal of Virology·Kevin WhitbyMichael S Diamond
Oct 26, 2005·Bioorganic & Medicinal Chemistry Letters·Zheng YinThomas H Keller
Oct 26, 2005·Bioorganic & Medicinal Chemistry Letters·Zheng YinThomas H Keller
Mar 30, 2006·Antimicrobial Agents and Chemotherapy·Francesc Puig-BasagoitiPei-Yong Shi
Jun 8, 2006·Environmental and Molecular Mutagenesis·James J Kohler, William Lewis
Jun 9, 2006·The Journal of General Virology·Ratree TakhampunyaRadhakrishnan Padmanabhan
Aug 9, 2006·The Journal of General Virology·Indira UmareddySubhash G Vasudevan
Dec 26, 2006·The International Journal of Biochemistry & Cell Biology·Niklaus H MuellerR Padmanabhan
Mar 6, 2007·Virology·Laura B Talarico, Elsa B Damonte
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·J J H Chu, Priscilla L Yang
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ana P GoncalvezChing-Juh Lai

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Citations

Mar 15, 2016·Journal of the American Chemical Society·Wan-Na ChenGottfried Otting
May 31, 2016·European Journal of Medicinal Chemistry·Milind SaudiArthur Van Aerschot
Oct 18, 2016·European Journal of Medicinal Chemistry·Akkaladevi VenkateshamArthur Van Aerschot
Oct 25, 2016·FEBS Letters·Natalia GrubaKrzysztof Pyrć
Apr 8, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Jenny KouretovaTorsten Steinmetzer
Apr 28, 2017·PloS One·Dachao LiangKai Man Kam
Feb 22, 2017·Bioorganic & Medicinal Chemistry Letters·Cyrille S KoundeFumiaki Yokokawa
Oct 21, 2016·F1000Research·Sean EkinsCarolina H Andrade
Mar 15, 2018·Antiviral Chemistry & Chemotherapy·Luděk EyerDaniel Růžek
Sep 28, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Rachel P M AbramsAvindra Nath
Oct 18, 2016·F1000Research·Sean EkinsCarolina H Andrade
Feb 27, 2019·Biophysics Reviews·Christoph Nitsche
Nov 28, 2019·Journal of Computer-aided Molecular Design·Stephen J BarigyeJuan A Castillo-Garit
Aug 3, 2016·Annual Review of Pharmacology and Toxicology·Maaike EvertsRichard J Whitley
Jun 11, 2020·International Journal of Molecular Sciences·Fu-Kai ChuangLi-Chen Yen
Sep 29, 2020·Frontiers in Immunology·Inmaculada Sanclemente-AlamanUlises Gómez-Pinedo
Sep 23, 2020·ChemMedChem·Tommaso FelicettiRolando Cannalire
Dec 6, 2018·Current Medicinal Chemistry·Adib Afandi AbdullahChoon Han Heh
Nov 20, 2020·European Journal of Medicinal Chemistry·Tommaso FelicettiGiuseppe Manfroni
Jul 19, 2019·Biosensors & Bioelectronics·J R AnushaC Justin Raj
Jan 27, 2021·European Journal of Medicinal Chemistry·Belén Martinez-GualdaSteven De Jonghe
Jan 23, 2021·RSC Medicinal Chemistry·Fumiaki Yokokawa
Apr 24, 2021·Future Medicinal Chemistry·Stephen J BarigyeJuan A Castillo-Garit
Jul 24, 2021·European Journal of Medicinal Chemistry·Crystall SwarbrickGerasimos Rassias
Jul 19, 2021·European Journal of Medicinal Chemistry·Igor José Dos Santos NascimentoEdeildo Ferreira da Silva-Júnior
Feb 16, 2018·Biochemistry·Alan C GibbsGaetano T Montelione
Aug 29, 2018·Journal of Medicinal Chemistry·Dorothée BardiotArnaud Marchand

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