PMID: 11900883Mar 20, 2002Paper

The medullary dorsal reticular nucleus as a pronociceptive centre of the pain control system

Progress in Neurobiology
D Lima, A Almeida

Abstract

The endogenous pain control system has long been considered as engaged in pain depression through the commitment of multiple descending actions that reduce the response capacity of spinal dorsal horn nociceptive neurones. Such a pure inhibitory antinociceptive nature was lately questioned by the observation of pronociceptive effects from areas classically regarded as antinociceptive. The thereby raised hypothesis of a more versatile functional arrangement that dynamically adjusts the pain modulatory effect to multiple conditions by balancing several excitatory and inhibitory actions found strong support on the recent discovery of a medullary area particularly dedicated to pain facilitation. Lesioning the medullary dorsal reticular nucleus (DRt) depresses nociceptive responses to acute and inflammatory pain, whereas stimulation produces the inverse effect. The decrease in formalin-induced pain behaviour following DRt lesioning is accompanied by a decrease of spinal noxious-evoked c-fos neuronal activation. DRt blocking by lidocaine results in a decrease of the nociceptive activity of spinal dorsal horn neurones, whereas stimulation by glutamate has the opposite effect. A reciprocal disynaptic putative excitatory circuit that lin...Continue Reading

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Citations

Nov 6, 2009·Current Pain and Headache Reports·Michael T SmithAdeel Nasir
Mar 31, 2004·Neuroscience Letters·Filipa Pinto-RibeiroNuno Sousa
Dec 5, 2002·Autonomic Neuroscience : Basic & Clinical·Vladimir A MaiskyHåkan Johansson
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Mar 10, 2011·Molecular Pain·Ricardo KusudaGuilherme Lucas
Jan 1, 2012·Scientifica·Michael H Ossipov
Jun 24, 2008·Journal of Chemical Neuroanatomy·Fani Lourença NetoJosé Manuel Castro-Lopes
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May 3, 2006·Pain·Nicoletta GaleottiCarla Ghelardini
Nov 19, 2002·Pain·Ke Ren, Ronald Dubner
Aug 3, 2002·The European Journal of Neuroscience·Armando AlmeidaDeolinda Lima

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