The melanoma epidemic: more apparent than real?

Mayo Clinic Proceedings
R A Swerlick, S Chen

Abstract

To examine inconsistencies between the growth in incidence of melanoma and more modest changes in melanoma-related mortality, we reviewed the medical literature on the incidence of melanoma diagnosis and associated mortality and on the changes in diagnosis and mortality over time. Increases in melanoma surveillance activity have been associated with increases in the diagnosis of thin melanomas, but the incidence of advanced tumors has changed minimally. The large increases in diagnosis of melanoma without commensurate increases in advanced tumors and mortality are not compatible with presumed malignant behavior of thin melanomas. Increased intensity of melanoma surveillance may artificially increase the incidence of melanoma by harvesting histologically "malignant" but biologically benign tumors. Little available evidence suggests the presence of an actual increase in the frequency of biologically malignant tumors. Attempts to increase screening intensity for melanoma may result in further increases in diagnosis of melanomas. Nevertheless, limitations in histopathologic diagnostic techniques will continue to hinder efforts at early identification of those at risk for death from melanoma without diagnosing melanoma in large numb...Continue Reading

Citations

Aug 6, 2005·BMJ : British Medical Journal·H Gilbert WelchLisa M Schwartz
Jul 1, 2006·Journal of General Internal Medicine·Marianne Berwick
Dec 29, 2007·Journal of Dermatological Case Reports·Paolo RomaGiuseppe Argenziano
Nov 11, 2016·Reviews in Endocrine & Metabolic Disorders·K KarimiRobert T Brodell
May 20, 2003·Journal of Cutaneous Pathology·Earl J Glusac
May 3, 2018·Journal of Cutaneous Medicine and Surgery·Annie LangleyYuka Asai
Feb 19, 2000·The Prostate·L K Dennis, M I Resnick
May 3, 2001·Journal of the National Cancer Institute·A JemalM A Tucker
Dec 4, 2004·Melanoma Research·Gerardo FerraraGiuseppe Argenziano
Oct 18, 2012·Journal of Cutaneous Pathology·Robin T Vollmer
May 28, 2016·CA: a Cancer Journal for Clinicians·Mary K TrippJeffrey E Gershenwald
Feb 4, 2016·Journal of Skin Cancer·Kehinde O RajiSuephy C Chen
Oct 8, 2003·The Oncologist·Frederick C Beddingfield
May 15, 2007·Melanoma Research·Elisabetta ChelliniLucia Giovannetti
Apr 24, 2010·Journal of the National Cancer Institute·H Gilbert Welch, William C Black
Feb 4, 2009·Journal of Cutaneous Pathology·Christine J KoEarl J Glusac
Oct 20, 2012·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Philipp TschandlHarald Kittler
Jan 1, 2015·Nature Reviews. Disease Primers·Dirk SchadendorfAxel Hauschild
Nov 22, 2014·Journal of Biomedical Optics·Jesse W WilsonWarren S Warren
May 29, 2003·Journal of Surgical Oncology·Eva MirandaAntonio Martínez Merino
Sep 25, 2012·Clinical and Experimental Dermatology·G D ReillyE Healy
Jun 10, 2005·ANZ Journal of Surgery·Edmund W EkTam Dieu
Jun 10, 2004·International Journal of Dermatology·Angeles Flórez, Manuel Cruces
Oct 12, 2010·Dermatology Research and Practice·Bizhan BandarchiGolnar Rasty
Feb 27, 2009·Upsala Journal of Medical Sciences·Antonis ValachisGiovanni Casazza
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan C GellerDonald R Miller
Sep 12, 2020·Personalized Medicine·Loren E ClarkeDavid E Elder
Jan 7, 2021·The New England Journal of Medicine·H Gilbert WelchAdewole S Adamson
Dec 20, 2008·Clinics in Dermatology·J Andrew CarlsonAndrze J Slominski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Dermatology
Angeles Flórez, Manuel Cruces
The Ocular Surface
Patrick Oellers, Carol L Karp
Archives of Pathology & Laboratory Medicine
Phyllis A Gimotty, DuPont Guerry
© 2021 Meta ULC. All rights reserved