The membrane as the gatekeeper of infection: Cholesterol in host-pathogen interaction

Chemistry and Physics of Lipids
G Aditya KumarAmitabha Chattopadhyay

Abstract

The cellular plasma membrane serves as a portal for the entry of intracellular pathogens. An essential step for an intracellular pathogen to gain entry into a host cell therefore is to be able to cross the cell membrane. In this review, we highlight the role of host membrane cholesterol in regulating the entry of intracellular pathogens using insights obtained from work on the interaction of Leishmania and Mycobacterium with host cells. The entry of these pathogens is known to be dependent on host membrane cholesterol. Importantly, pathogen entry is inhibited either upon depletion (or complexation), or enrichment of membrane cholesterol. In other words, an optimum level of host membrane cholesterol is necessary for efficient infection by pathogens. In this overall context, we propose a general mechanism, based on cholesterol-induced conformational changes, involving cholesterol binding sites in host cell surface receptors that are implicated in this process. A therapeutic strategy targeting modulation of membrane cholesterol would have the advantage of avoiding the commonly encountered problem of drug resistance in tackling infection by intracellular pathogens. Insights into the role of host membrane cholesterol in pathogen ent...Continue Reading

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Citations

Jul 3, 2016·Chemistry and Physics of Lipids·Richard M Epand, Amitabha Chattopadhyay
Dec 22, 2016·British Journal of Pharmacology·Areej Abuhammad
Aug 23, 2019·The Journal of Membrane Biology·Pranav Adhyapak, Shobhna Kapoor
Sep 4, 2019·Scientific Reports·G Aditya KumarAmitabha Chattopadhyay
Feb 8, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Parijat Sarkar, Amitabha Chattopadhyay
Sep 8, 2019·Scientific Reports·Manjari MishraShobhna Kapoor
Jul 15, 2020·Antimicrobial Agents and Chemotherapy·Sabrina MariottiMaria Cristina Gagliardi
Jul 2, 2017·Scientific Reports·Parijat SarkarAmitabha Chattopadhyay
Jan 12, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·G Aditya Kumar, Amitabha Chattopadhyay
Jun 26, 2020·The Journal of Physical Chemistry. B·Sandeep ShrivastavaAmitabha Chattopadhyay
Mar 24, 2021·Parasite Immunology·Supratim PradhanBudhaditya Mukherjee
Jul 6, 2021·Journal of Fluorescence·Amitabha ChattopadhyayAnunay Samanta
Nov 16, 2021·The Journal of Physical Chemistry Letters·Shankar PandeyHanbin Mao

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