The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes

Biological Chemistry
V KeitelD Häussinger

Abstract

Cholangiocyte cilia are sensory organelles that extend from the apical membrane into the bile duct lumen and detect changes in bile flow and osmolarity. Whether or not cholangiocyte cilia are responsive to bile acids is unknown. TGR5 (Gpbar-1) is a membrane-bound bile acid receptor which is expressed in biliary epithelial cells and promotes chloride secretion in gallbladder epithelial cells. As shown in the present study, TGR5 is localized in the primary cilium of mouse and human cholangiocytes. Here the receptor could play an important role in coupling biliary bile acid concentration and composition to ductular bile formation.

References

Apr 13, 1999·Neuroscience·M HändelV Höllt
Nov 1, 2001·The Journal of Membrane Biology·H A Praetorius, K R Spring
Nov 7, 2002·Biochemical and Biophysical Research Communications·Takaharu MaruyamaKenichi Tanaka
Jan 14, 2003·The Journal of Biological Chemistry·Yuji KawamataMasahiko Fujino
Jan 18, 2003·The Journal of Membrane Biology·H A Praetorius, K R Spring
Nov 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·J W GRISHAM
Nov 5, 2003·Gastroenterology·Tatyana V MasyukNicholas F LaRusso
Nov 7, 2003·Nature·Danwei HuangfuKathryn V Anderson
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Verena KeitelRalf Kubitz
Oct 26, 2005·Current Biology : CB·Linda SchneiderSøren T Christensen
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca FabrisMario Strazzabosco
May 27, 2006·The Biochemical Journal·Galya VassilevaEric L Gustafson
Jun 15, 2006·World Journal of Gastroenterology : WJG·Shannon GlaserGianfranco Alpini
Jun 15, 2006·World Journal of Gastroenterology : WJG·Xuefeng XiaGene LeSage
Aug 5, 2006·Science·Veena Singla, Jeremy F Reiter
Aug 11, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bing Q HuangNicholas F Larusso
Jan 24, 2007·Traffic·Søren T ChristensenPeter Satir
May 15, 2007·Molecular & Cellular Proteomics : MCP·Qin LiuEric A Pierce
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sergio A GradiloneNicholas F Larusso
Mar 28, 2008·Histochemistry and Cell Biology·Peter Satir, Søren T Christensen
May 13, 2008·Biochemical and Biophysical Research Communications·Verena KeitelDieter Häussinger
Aug 9, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anatoliy I MasyukNicholas F Larusso
Mar 12, 2009·Nephron. Physiology·Iben R VelandSøren T Christensen
Jul 8, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Verena KeitelDieter Häussinger

❮ Previous
Next ❯

Citations

Feb 8, 2011·In Vitro Cellular & Developmental Biology. Animal·Thomas J CapernaNeil C Talbot
Feb 4, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew S ChuRebecca G Wells
Jul 15, 2011·Experimental Diabetes Research·Xiaosong ChenWendong Huang
Jun 22, 2011·Digestive Diseases·Thijs W H PolsKristina Schoonjans
May 3, 2012·Journal of Lipid Research·Geoffrey PorezBart Staels
Apr 2, 2011·Molecular Endocrinology·Tingting LiDavid J Mangelsdorf
Jan 15, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Henri DubocAlan F Hofmann
Mar 14, 2014·Current Diabetes Reports·Morten HansenFilip K Knop
May 14, 2014·Nature Reviews. Endocrinology·Folkert KuipersAlbert K Groen
Nov 10, 2015·Expert Review of Clinical Pharmacology·Palak J TrivediM Eric Gershwin
Dec 27, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bryan L Copple, Tiangang Li
Jul 17, 2012·Clinics and Research in Hepatology and Gastroenterology·Ralf KubitzDieter Häussinger
Apr 24, 2012·Clinics and Research in Hepatology and Gastroenterology·Verena Keitel, Dieter Häussinger
Sep 21, 2010·Gastroenterology·Gideon M HirschfieldM Eric Gershwin
Mar 2, 2016·Current Opinion in Cell Biology·Keren I HilgendorfPeter K Jackson
Nov 7, 2015·Trends in Pharmacological Sciences·Alessia Perino, Kristina Schoonjans
Oct 19, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna BaghdasaryanMichael Trauner
Apr 23, 2013·Journal of Hepatology·Tom H Karlsen, Kirsten Muri Boberg
Apr 29, 2015·Journal of Hepatology·Ulrich BeuersRaoul Poupon
Dec 15, 2010·Journal of Hepatology·Thijs W H PolsKristina Schoonjans
Jun 21, 2013·Journal of Receptor and Signal Transduction Research·Vanesa StepanovMomir Mikov
Feb 24, 2016·Expert Opinion on Emerging Drugs·Ahmad H AliKeith D Lindor
Mar 18, 2017·Molecular Aspects of Medicine·Grégory MerlenThierry Tordjmann
May 17, 2017·Molecular Aspects of Medicine·Saraid McIlvrideCatherine Williamson
Jun 27, 2017·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Keisaku SatoGianfranco Alpini
Jun 22, 2011·Digestive Diseases·Johannes R HovTom H Karlsen
Mar 22, 2014·Biochemical Society Transactions·Thijs W H Pols
Apr 17, 2019·Expert Opinion on Therapeutic Targets·Keisaku SatoGianfranco Alpini
Dec 18, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Sarah TonackStefan Offermanns
Aug 25, 2015·EMBO Reports·Kenneth Bødtker SchouSøren Tvorup Christensen
Aug 21, 2014·Clinical Reviews in Allergy & Immunology·Verena KeitelDieter Häussinger
Sep 28, 2016·World Journal of Gastroenterology : WJG·Hui-Yi Feng, Yang-Chao Chen
Mar 8, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Grégory MerlenThierry Tordjmann
Jun 19, 2019·Diabetes & Metabolism Journal·Jessica M Ferrell, John Y L Chiang
Feb 23, 2013·Current Opinion in Gastroenterology·Verena Keitel, Dieter Häussinger
Aug 2, 2012·Clinical Pharmacology and Therapeutics·L J Maillette de Buy WennigerU Beuers
Mar 28, 2012·Current Opinion in Gastroenterology·Ulrich BeuersRonald O Elferink
Apr 13, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anatoliy I MasyukNicholas F LaRusso
Feb 9, 2019·Nature Reviews. Nephrology·Zeinab AnvarianSøren Tvorup Christensen
May 18, 2019·Purinergic Signalling·Axel SchmidtDominik Wiemuth
Feb 6, 2017·Cold Spring Harbor Perspectives in Biology·Kirk Mykytyn, Candice Askwith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
V KeitelD Häussinger
Digestive Diseases
V Keitel, D Häussinger
Biochemical and Biophysical Research Communications
V KeitelD Häussinger
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
V KeitelR Kubitz
© 2021 Meta ULC. All rights reserved