The membrane pacemaker hypothesis: novel tests during the ontogeny of endothermy

The Journal of Experimental Biology
Edwin R PriceEdward M Dzialowski

Abstract

The 'membrane pacemaker' hypothesis proposes a biochemical explanation for among-species variation in resting metabolism, based on the positive correlation between membrane docosahexaenoic acid (DHA) and metabolic rate. We tested this hypothesis using a novel model, altricial red-winged blackbird nestlings, predicting that the proportion of DHA in muscle and liver membranes should increase with the increasing metabolic rate of the nestling as it develops endothermy. We also used a dietary manipulation, supplementing the natural diet with fish oil (high DHA) or sunflower oil (high linoleic acid) to alter membrane composition and then assessed metabolic rate. In support of the membrane pacemaker hypothesis, DHA proportions increased in membranes from pectoralis muscle, muscle mitochondria and liver during post-hatch development. By contrast, elevated dietary DHA had no effect on resting metabolic rate, despite causing significant changes to membrane lipid composition. During cold challenges, higher metabolic rates were achieved by birds that had lower DHA and higher linoleic acid in membrane phospholipids. Given the mixed support for this hypothesis, we conclude that correlations between membrane DHA and metabolic rate are likely...Continue Reading

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Citations

Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tommy Norin, Neil B Metcalfe
Jun 30, 2019·The Journal of Experimental Biology·Edwin R PriceEdward M Dzialowski
Mar 25, 2021·The Journal of Experimental Biology·Caroline Cristina-SilvaKênia Cardoso Bícego

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