PMID: 6112049May 18, 1981Paper

The membrane potential of cat hippocampal neurons recorded in vivo displays four different reaction-mechanisms to iontophoretically applied transmitter agonists

Brain Research
P L Herrling

Abstract

Intracellular recordings were obtained in vivo from cat hippocampal pyramidal cells and cells in deeper layers of the hippocampal formation. Five transmitter agonists were applied to these cells by microiontophoresis. Glutamate caused depolarizations with fast onset and decay, fastest reaction times being within hundreds of msec of the beginning and the of the application. These depolarizations were accompanied by a decrease of the apparent input resistance (AIR) and an increase of the mean firing rate. Carbachol, a cholinergic agonist, caused depolarizations with slow onset and decay, reaction times were in the range of tens of seconds. The depolarizations were also accompanied by an increase in the mean firing rate. These effects are thought to be muscarinic. gamma-Aminobutyric acid elicited fast hyperpolarizations, a decrease of the AIR, mean firing rate and occasionally of the amplitude of action potentials (APs). Dopamine and norepinephrine hyperpolarized the membrane potential relatively fast, reaction times being within seconds, and reduced the mean firing rate, but this was accompanied by a marked increase of the AIR, of the size of the remaining APs and fimbria-evoked EPSPs. Inhibitory slow depolarizations of the type ...Continue Reading

References

Mar 3, 1980·Brain Research·P A Schwartzkroin, D A Prince

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Citations

Jul 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·P L Herrling, B Misbach-Lesenne
Jan 1, 1984·Pflügers Archiv : European journal of physiology·H L HaasD O Carpenter
Apr 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·E I Solntseva, O V Borisova
Oct 28, 1982·Brain Research·J V Halliwell, P R Adams
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·R D Oades
May 1, 1987·Brain Research·R D Oades, G M Halliday
Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·C W Harley
Aug 14, 1990·Neuroscience Letters·R M Torack, J C Morris
Jul 1, 1994·General Pharmacology·Y Gao, J W Phillis
Jan 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·A GasbarriM G Packard
Jan 1, 1988·Annals of the New York Academy of Sciences·G J MogensonC Y Yim
Sep 1, 1990·Neurophysiologie clinique = Clinical neurophysiology·M SabatinoV La Grutta
Jun 5, 2001·Nature Reviews. Neuroscience·A R Cantrell, W A Catterall
Jan 1, 1990·Journal of Neural Transmission. General Section·M CampsJ M Palacios

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