The Membrane Protein Sortilin Can Be Targeted to Inhibit Pancreatic Cancer Cell Invasion

The American Journal of Pathology
Fangfang GaoHubert Hondermarck

Abstract

Pancreatic cancer has a dismal prognosis, and there is no targeted therapy against this malignancy. The neuronal membrane protein sortilin is emerging as a regulator of cancer cell development, but its expression and impact in pancreatic cancer are unknown. This study found that sortilin expression was higher in pancreatic cell lines versus normal pancreatic ductal epithelial cells, as shown by Western blot analysis and mass spectrometry. The increased sortilin level in pancreatic cancer cells was confirmed by immunohistochemistry in a series of 99 human pancreatic adenocarcinomas versus 48 normal pancreatic tissues (P = 0.0014). Sortilin inhibition by siRNA and the pharmacologic inhibitor AF38469 strongly reduced the adhesion and invasion of pancreatic cancer cells without affecting cell survival and viability. Sortilin inhibition also decreased the phosphorylation of the focal adhesion kinase in Tyr925. Together, these data show that sortilin contributes to pancreatic cancer invasion and could eventually be targeted in therapy.

References

Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Louis F Reichardt
Oct 24, 2009·FEBS Letters·Tobias MaierLuis Serrano
Apr 27, 2010·Current Opinion in Cell Biology·Jonathan S Bogan, Konstantin V Kandror
Nov 26, 2010·Nature Neuroscience·Christian B VaegterAnders Nykjaer
Feb 4, 2011·Molecular Biology of the Cell·Therese B DeramaudtPhilippe Rondé
Mar 14, 2012·Nature Reviews. Genetics·Christine Vogel, Edward M Marcotte
Dec 21, 2013·Bioorganic & Medicinal Chemistry Letters·Tenna Juul SchrøderStephen P Watson
Feb 6, 2014·The European Journal of Neuroscience·Gary R Lewin, Anders Nykjaer
Jul 22, 2014·Nature·Bing ZhangUNKNOWN NCI CPTAC
Aug 8, 2014·Nature Reviews. Cancer·Florian J SulzmaierDavid D Schlaepfer
Oct 7, 2014·The American Journal of Pathology·Jay PundavelaHubert Hondermarck
Dec 11, 2014·Advances in Biological Regulation·Ralph A BradshawHubert Hondermarck
Mar 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jami L SalomanBrian M Davis
Mar 8, 2016·The Journal of Clinical Investigation·Claudia GoettschElena Aikawa
May 10, 2016·Nature Reviews. Disease Primers·Jorg KleeffJohn P Neoptolemos
Nov 12, 2016·International Journal of Molecular Sciences·Sophie Béraud-DufourJean Mazella
Apr 5, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gulam Abbas ManjiPaul Oberstein
Oct 19, 2017·The American Journal of Pathology·Sam FaulknerHubert Hondermarck
Nov 1, 2017·Nature Communications·Hussein Al-AkhrassFabrice Lalloué
Dec 23, 2017·Neoplasia : an International Journal for Oncology Research·Ji Tae KimB Mark Evers
Nov 14, 2018·Cancer Cell·Bernhard W RenzTimothy C Wang
Jan 23, 2019·Frontiers in Pharmacology·Hugo TalbotMarie-Odile Jauberteau
Jan 31, 2019·Frontiers in Pharmacology·Nicolas BlondeauThierry Coppola
Mar 6, 2019·World Journal of Oncology·Prashanth RawlaVinaya Gaduputi
Apr 5, 2019·Cancer Discovery·Sam FaulknerHubert Hondermarck
Jun 22, 2019·Science Advances·Mette RichnerAnders Nykjær
Aug 23, 2019·Histopathology·Iris D NagtegaalUNKNOWN WHO Classification of Tumours Editorial Board

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