PMID: 16530275DOI: 10.1016/j.antiviral.2006.02.002Mar 15, 2006Paper
The membranes' role in the HIV-1 neutralizing monoclonal antibody 2F5 mode of action needs re-evaluation
Antiviral Research
Ana Salomé Veiga, Miguel A R B Castanho
Abstract
2F5, a monoclonal antibody that neutralizes HIV-1 primary isolates, recognizes an epitope in the membrane proximal region of the glycoprotein gp41 ectodomain. It is believed that binding to the viral membrane is a step in the antibody mode of action, as usual in ligand membrane receptor interactions. We investigated the interaction of 2F5 with membrane model systems, namely large unilamellar vesicles, by means of fluorescence techniques. There were no significant interactions of 2F5 with model viral membranes or with model target cell membranes. Thus, the usual three-step 'membrane catalysis' method is not followed by 2F5 in its mode of action.
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Citations
Jan 20, 2011·AIDS·Henri G FranquelimMiguel A R B Castanho
Sep 28, 2012·Journal of Virology·F BenjellounS Paul
Nov 18, 2011·Journal of Virology·Ramesh RathinakumarKenneth H Roux
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Feb 16, 2010·Biochimica Et Biophysica Acta·Henri G FranquelimMiguel A R B Castanho
Mar 14, 2009·Chembiochem : a European Journal of Chemical Biology·Ana S VeigaMarie Isabel Aguilar
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