The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice

Pharmacology, Biochemistry, and Behavior
Eunji KimJong Hoon Ryu

Abstract

Erucic acid is a monounsaturated omega-9 fatty acid isolated from the seed of Raphanus sativus L. that is known to normalize the accumulation of very long chain fatty acids in the brains of patients suffering from X-linked adrenoleukodystrophy. Here, we investigated whether erucic acid enhanced cognitive function or ameliorated scopolamine-induced memory impairment using the passive avoidance, Y-maze and Morris water maze tasks. Erucic acid (3mg/kg, p.o.) enhanced memory performance in normal naïve mice. In addition, erucic acid (3mg/kg, p.o.) ameliorated scopolamine-induced memory impairment, as assessed via the behavioral tasks. We then investigated the underlying mechanism of the memory-enhancing effect of erucic acid. The administration of erucic acid increased the phosphorylation levels of phosphatidylinositide 3-kinase (PI3K), protein kinase C zeta (PKCζ), extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB) and additional protein kinase B (Akt) in the hippocampus. These results suggest that erucic acid has an ameliorative effect in mice with scopolamine-induced memory deficits and that the effect of erucic acid is partially due to the activation of PI3K-PKCζ-ERK-CREB signaling as well...Continue Reading

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Citations

Mar 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenwen LianGuan-Hua Du
Jun 22, 2019·Journal of Medicinal Food·Yulan LiaoJong Hoon Ryu
Mar 5, 2019·Biological & Pharmaceutical Bulletin·Yulan LiaoJong Hoon Ryu
Nov 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Malena Martínez PérezMaria de Lourdes Teixeira de Moraes Polizeli
Jan 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yang XinHu Guoyan
Mar 5, 2020·Annals of General Psychiatry·Fatemeh FatemiGity Sotoudeh
Jan 12, 2021·Journal of Alzheimer's Disease : JAD·Burcu F DarstCorinne D Engelman
Oct 16, 2020·Nutritional Neuroscience·J B Senthil Kumar, Bhawna Sharma

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