The metabolic cost of mounting an immune response in male brown anoles (Anolis sagrei)

Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology
Christian L CoxRobert M Cox

Abstract

The tradeoff between reproduction and survival is central to life-history theory and is thought to reflect underlying energetic tradeoffs between reproduction and self-maintenance. Immune responses to parasites and pathogens are important components of self-maintenance in many species, but whether these defenses impose significant energetic costs has only been tested in a handful of organisms. We tested for a metabolic cost of mounting an immune response in the male brown anole (Anolis sagrei), a lizard in which we have previously shown that reproduction causes a marked reduction in immune response to the novel antigen phytohaemagglutinin (PHA). We treated captive male anoles with a subcutaneous injection of either PHA, which induces an immune response that manifests as localized swelling, or saline vehicle as a control. Prior to injection and at 24, 48, and 72 hr post-injection, we measured swelling at the site of injection and whole-animal resting metabolic rate (RMR) using stop-flow respirometry. Although we detected a robust swelling response to PHA at 24, 48, and 72 hr post-injection, mean RMR did not differ between treatments at any of these time points. However, within the PHA treatment group, RMR increased with the exte...Continue Reading

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Citations

Jul 13, 2016·Developmental and Comparative Immunology·Helmut SegnerMagdalena Chadzinska
Sep 5, 2015·Personality and Social Psychology Review : an Official Journal of the Society for Personality and Social Psychology, Inc·Gabrielle Filip-Crawford, Steven L Neuberg
Apr 14, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Geoffrey D SmithSusannah S French
Apr 24, 2020·The Journal of Experimental Biology·Craig M LindTerence M Farrell
May 13, 2021·Proceedings. Biological Sciences·Tyler N Wittman, Robert M Cox

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