The metabolic effects of interleukin 1 beta on human bone marrow adipocytes

Cytokine
S E DelikatM Zuzel

Abstract

We have recently shown that interleukin 1 beta (IL-1 beta) directly reduces the number of adipocytes in cultures of human bone marrow (BM) stromal cells. The aim of the present study was to establish the mechanisms involved in the IL-1 effect and thereby assess its importance in BM pathophysiology. Direct morphological observation showed that individual adipocytes lost their fat in the presence of IL-1 beta and regained it when the cytokine was withdrawn. These morphological observations were supported by metabolic studies using [14]acetate as a precursor of storage fat. These metabolic studies showed that IL-1 beta inhibited the incorporation of label into triglycerides. In addition, the cytokine enhanced the release of radioactivity from prelabelled adipocytes and reduced their triglyceride stores. It was therefore concluded that IL-1 beta can both inhibit lipogenesis and stimulate lipolysis in BM adipocytes. Forskolin (an adenylate cyclase activator) produced lipolytic effect similar to those of IL-1 beta, while indomethacin (an inhibitor of prostaglandin [PG] production) fully blocked the release of radioactivity induced by IL-1 beta and greatly increased triglyceride synthesis. However, IL-1 beta was still able to decrease...Continue Reading

Citations

Feb 28, 2013·Diabetologia·M P CzechM Aouadi
Feb 9, 2000·Progress in Lipid Research·C M Pond
Aug 25, 2009·The Proceedings of the Nutrition Society·Véronic Bézaire, Dominique Langin
Nov 30, 2000·Critical Care : the Official Journal of the Critical Care Forum·C Weissman

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