The metabolic landscape of cancer stem cells

IUBMB Life
Ilaria DandoMassimo Donadelli

Abstract

Cancer stem cells (CSCs) are a sub-population of quiescent cells endowed with self-renewal properties that can sustain the malignant behavior of the tumor mass giving rise to more differentiated cancer cells. For this reason, the specific killing of CSCs represents one of the most important challenges of the modern molecular oncology. However, their particular resistance to traditional chemotherapy and radiotherapy imposes a thorough understanding of their biological and biochemical features. The metabolic peculiarities of CSCs may be a therapeutic and diagnostic opportunity in cancer research. In this review, we summarize the most significant discoveries on the metabolism of CSCs describing and critically analyzing the studies supporting either glycolysis or mitochondrial oxidative phosphorylation as a primary source of energy for CSCs.

References

Apr 2, 2005·Nature Reviews. Cancer·Michael DeanSusan Bates
Jul 5, 2005·Current Medicinal Chemistry. Anti-cancer Agents·Sudha SharmaRobert M Brosh
Dec 24, 2005·Expert Opinion on Investigational Drugs·Józefa Wesierska-Gadek, Gerald Schmid
Sep 28, 2006·Annual Review of Medicine·Piero DalerbaMichael F Clarke
Aug 21, 2007·Radiologic Clinics of North America·Norbert Avril, Lee P Adler
Aug 5, 2010·Cell Stem Cell·Ahmed MohyeldinAlfredo Quiñones-Hinojosa
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Sep 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Erina VlashiFrank Pajonk
Jan 1, 2010·Cancer Biomarkers : Section a of Disease Markers·Ewa NowosinskaNorbert Avril
Nov 26, 2011·Cell Death and Differentiation·M BartucciR De Maria
Jan 24, 2012·Cell·Andrew D RhimBen Z Stanger
Aug 18, 2012·Genes & Development·Michalina JaniszewskaIvan Stamenkovic
Dec 12, 2012·Clinical Chemistry·Nemanja D MarjanovicChristine L Chaffer
Feb 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Khaled A HassanMax S Wicha
Mar 23, 2013·Cancer Cell·Michael S Schieber, Navdeep S Chandel
Apr 4, 2013·Cell Cycle·Javier A MenendezAlejandro Vazquez-Martin
May 21, 2013·Acta Pharmacologica Sinica·Ke ChenJi-long Chen
Jul 10, 2013·Journal of Proteomics·Benjamin L EmminkOnno Kranenburg
Aug 22, 2013·Breast Cancer Research and Treatment·Claudia FumarolaMara A Bonelli
Sep 3, 2013·Nature Neuroscience·William A FlavahanAnita B Hjelmeland
Sep 14, 2013·Journal of Cellular Biochemistry·Roberta PaloriniFerdinando Chiaradonna
Sep 26, 2013·Nature Reviews. Cancer·Benjamin Beck, Cédric Blanpain
Feb 27, 2014·Biochimica Et Biophysica Acta·Daniele Lettieri BarbatoMaria Rosa Ciriolo
Jul 11, 2014·Breast Cancer Research and Treatment·Erina VlashiFrank Pajonk
Oct 18, 2014·Frontiers in Oncology·Javier A Menendez, Tomás Alarcón

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Citations

May 26, 2016·Breast Cancer Research : BCR·Maria Peiris-PagèsMichael P Lisanti
Mar 15, 2018·Journal of Cellular Biochemistry·Tulika MitraSib S Roy
May 10, 2018·European Journal of Nutrition·Jina ChoiSang-Woon Choi
Apr 14, 2018·Cell Death and Differentiation·Harvey R FernandezMaria Laura Avantaggiati
May 11, 2018·The Biochemical Journal·Ernestina M De FrancescoMichael P Lisanti
Jun 21, 2018·Frontiers in Oncology·Vusala SnyderShrikant Anant
Oct 2, 2020·Cancers·Atsushi Tanabe, Hiroeki Sahara
Sep 19, 2017·Current Stem Cell Reports·Ahmet AlptekinHan-Fei Ding
Jul 13, 2018·Cancer Communications·Ching-Ying Kuo, David K Ann

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