The Metabolic Pattern of Idiopathic REM Sleep Behavior Disorder Reflects Early-Stage Parkinson Disease

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Sanne K MelesREMPET Study Group

Abstract

Idiopathic REM sleep behavior disorder (iRBD) is considered a prodromal stage of Parkinson disease (PD) and other Lewy body disorders. Spatial covariance analysis of 18F-FDG PET data has disclosed a specific brain pattern of altered glucose metabolism in PD. In this study, we identify the metabolic pattern underlying iRBD and compare it with the known PD pattern. To understand the relevance of the iRBD pattern to disease progression, we studied the expression of the iRBD pattern in de novo PD patients. Methods: The iRBD-related pattern was identified in 18F-FDG PET scans of 21 patients with polysomnographically confirmed iRBD and 19 controls using spatial covariance analysis. Expression of the iRBD-related pattern was subsequently computed in 18F-FDG PET scans of 44 controls and 38 de novo, treatment-naïve PD patients. Of these 38 PD patients, 24 had probable REM sleep behavior disorder (RBD) according to the Mayo Sleep Questionnaire. Neuropsychologic evaluation showed mild cognitive impairment in 20 PD patients (PD-MCI), of whom 16 also had concomitant RBD and roughly half (11/20) had bilateral motor symptoms. Results: The iRBD-related pattern was characterized by relative hypermetabolism in the cerebellum, brain stem, thalamu...Continue Reading

References

Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D EidelbergS Przedborski
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Jun 29, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yilong MaDavid Eidelberg
Mar 18, 2008·NeuroImage·Christian HabeckYaakov Stern
Jun 16, 2009·NeuroImage·Noam I KerenMark A Eckert
Jan 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chris C TangDavid Eidelberg
May 5, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Mélanie VendetteJacques Montplaisir
May 17, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nicolaas I BohnenDavid E Kuhl
Jun 8, 2011·Frontiers in Systems Neuroscience·Claire DelavilleAbdelhamid Benazzouz
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Georg S KranzRupert Lanzenberger
Aug 9, 2012·European Journal of Nuclear Medicine and Molecular Imaging·David Garcia-GarciaMaria C Rodriguez-Oroz
Sep 4, 2012·Annals of Neurology·Martin Niethammer, David Eidelberg
Nov 2, 2012·Neurology·Thien Thanh Dang-VuJacques Montplaisir
Mar 14, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Laura K TeuneKlaus L Leenders
Jul 3, 2013·Experimental Brain Research·Philippe Huot, Susan H Fox
Jan 24, 2014·Neurology·Florian HoltberndJacques Montplaisir
Mar 29, 2014·Trends in Neurosciences·John PeeverJacques Montplaisir
Jun 24, 2014·Neuroinformatics·Pasquale Anthony Della RosaUNKNOWN EADC-PET Consortium
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Phoebe G SpetsierisDavid Eidelberg
Jul 30, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jingjie GeJian Wang
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaGünther Deuschl
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Mar 23, 2017·Current Neurology and Neuroscience Reports·Seyed-Mohammad Fereshtehnejad, Ronald B Postuma
Jul 25, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Sanne K MelesWolfgang H Oertel

❮ Previous
Next ❯

Citations

Feb 12, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhemin HuangPing Wu
Apr 6, 2019·Journal of Neural Transmission·Rezzak YilmazDaniela Berg
Jun 11, 2019·Journal of Clinical and Experimental Neuropsychology·Krista SpecketerBrenna A Cholerton
May 3, 2019·International Journal of Neural Systems·Octavio Martinez ManzaneraNatasha M Maurits
Dec 25, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Katharina A SchindlbeckDavid Eidelberg
Jul 12, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Rosalie V KoganUNKNOWN JPND-PETMETPAT Working Group
Mar 15, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G CarliD Perani
Feb 12, 2019·Journal of Parkinson's Disease·Dario ArnaldiUNKNOWN REMPET Study Group
Jul 7, 2019·Expert Review of Neurotherapeutics·Luigi Ferini-StrambiAndrea Galbiati
Sep 15, 2020·Journal of Parkinson's Disease·Chris C TangDavid Eidelberg
Sep 5, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Yvette C WongLaura A Volpicelli-Daley
Aug 3, 2019·Alcoholism, Clinical and Experimental Research·Ludivine RitzAnne Lise Pitel
Dec 4, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yonglu ChenBiao Huang
Oct 22, 2020·Journal of Neurology·Michael J FirbankAlan J Thomas
Jan 13, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·David J Brooks
Jan 30, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Pietro MattioliDario Arnaldi
Apr 1, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Ryul KimBeomseok Jeon
Apr 4, 2021·Brain Sciences·Giulia CarliDaniela Perani
Apr 25, 2021·Lancet Neurology·Eduardo TolosaWerner Poewe
Sep 18, 2021·Molecular Medicine·Sanne K MelesKlaus L Leenders
Nov 20, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Annette JanzenWolfgang H Oertel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.