The metabolic syndrome in a memory clinic population: relation with clinical profile and prognosis

Journal of the Neurological Sciences
Lieza G ExaltoG J Biessels

Abstract

The metabolic syndrome (MetS) refers to a cluster of cardiovascular risk factors that is associated with an increased risk of cognitive impairment and dementia. It is unclear however, if the presence of the MetS is associated with a particular clinical profile or a different prognosis in patients with cognitive complaints or early dementia. To compare 1) the clinical profile and 2) the prognosis of patients attending a memory clinic according to the presence or absence of MetS. Longitudinal cohort. Memory clinic. We included and followed 86 consecutive patients (average age of 66.7 (SD 9.7)) from the Amsterdam Dementia Cohort with an MMSE>22. Clinical profile (neuropsychological examination, brain MRI, cerebrospinal fluid (CSF) biomarkers, clinical diagnosis) on an initial standardized diagnostic assessment was compared according to MetS status. Progression to dementia was assessed in initially nondemented patients (subjective complaints n=40, mild cognitive impairment n=24, follow-up available in 59). 35 (41%) patients met the MetS criteria. Demographics were similar between patients with or without the MetS. At baseline, diagnosis, cognitive performance, severity of degenerative or vascular abnormalities on MRI, and CSF amylo...Continue Reading

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Citations

Dec 20, 2017·Journal of Alzheimer's Disease : JAD·Whitney WhartonPatrick G Kehoe
Feb 5, 2019·Climacteric : the Journal of the International Menopause Society·P Chedraui, F R Pérez-López
Dec 24, 2019·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Nina Coll-PadrósLorena Rami
Aug 15, 2018·Journal of Alzheimer's Disease : JAD·Gabriela GomezSusan M Resnick

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