Abstract
Metabolic syndrome (MetS), a set of metabolic risk factors including obesity, dysglycemia, and dyslipidemia, is associated with increased colorectal cancer (CRC) risk. A putative biological mechanism is chronic, low-grade inflammation, both a feature of MetS and a CRC risk factor. However, excess body fat also induces a proinflammatory state and increases CRC risk. In order to explore the relationship between MetS, body size, inflammation, and CRC, we studied large panels of inflammatory and cancer biomarkers. We included 138 participants from the Västerbotten Intervention Programme with repeated sampling occasions, 10 years apart. Plasma samples were analyzed for 178 protein markers by proximity extension assay. To identify associations between plasma protein levels and MetS components, linear mixed models were fitted for each protein. Twelve proteins were associated with at least one MetS component, six of which were associated with MetS score. MetS alone was not related to any protein. Instead, BMI displayed by far the strongest associations with the biomarkers. One of the 12 MetS score-related proteins (FGF-21), also associated with BMI, was associated with an increased CRC risk (OR 1.71, 95% CI 1.19-2.47). We conclude that...Continue Reading
References
Oct 3, 2002·Nature Reviews. Molecular Cell Biology·Gary Thomas
Feb 17, 2005·The Journal of Clinical Endocrinology and Metabolism·Akiko HiratsukaTsutomu Imaizumi
Jun 29, 2005·Diabetes Care·Earl S Ford
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yi RenJohn Wong
Sep 15, 2005·Circulation·Scott M GrundyUNKNOWN National Heart, Lung, and Blood Institute
Sep 27, 2006·The American Journal of Medicine·Andrea GalassiJiang He
Sep 7, 2007·Cancer Research·Ivan P GorlovChristopher I Amos
Feb 7, 2008·Diabetes·Xinmei ZhangAimin Xu
Feb 16, 2008·Annals of Human Biology·Yulia VistoropskyGregory Livshits
Apr 9, 2008·Neoplasia : an International Journal for Oncology Research·Julia M CoppolaAlnawaz Rehemtulla
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeremy M G TaylorRebecca R Andridge
Feb 28, 2009·Nature Reviews. Drug Discovery·Andrew Beenken, Moosa Mohammadi
Apr 17, 2009·Current Opinion in Lipidology·Sridevi DevarajIshwarlal Jialal
Nov 13, 2009·The American Journal of Clinical Nutrition·Steven A Kliewer, David J Mangelsdorf
Mar 27, 2010·Global Health Action·Margareta NorbergLars Weinehall
Aug 26, 2010·Cancer Science·Na Young JiEun Young Song
Nov 26, 2010·Journal of Digestive Diseases·Arthur J McCullough
Apr 21, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Susan Kralisch, Mathias Fasshauer
Jun 24, 2011·Cancer Prevention Research·Krasimira AleksandrovaTobias Pischon
Sep 14, 2011·International Journal of Biological Sciences·Sandra BraunDerek LeRoith
Oct 7, 2011·Endocrine Research·Xingbo ChengHuaying Fan
Jun 28, 2012·Cellular Signalling·Yun Hee KangEun Young Song
Aug 23, 2012·PloS One·Xiaoyi HuangPei Zhong
Oct 25, 2012·Diabetes Care·Katherine EspositoDario Giugliano
Nov 7, 2012·The Journal of Endocrinology·Susan KralischMathias Fasshauer
Apr 3, 2013·Endocrine·Katherine EspositoDario Giugliano
Apr 9, 2014·Cardiology Research and Practice·Jaspinder Kaur
Jul 11, 2014·Diabetes·Kathleen R MarkanMatthew J Potthoff
Dec 3, 2014·Metabolism: Clinical and Experimental·Fernando Miguel MendonçaCristina Abreu
Jun 4, 2015·Diabetes & Metabolism·J HardingD J Magliano
Jul 25, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Francine K WeltyTarec K Elajami
Sep 26, 2015·Biomedical Reports·Chikara UeyamaYoshiji Yamada
Jan 28, 2016·International Journal of Medical Sciences·Krithika SrikanthanKomal Sodhi
Jul 1, 2016·Journal of Molecular Biomarkers & Diagnosis·M E KnottM S De Lorenzo
Oct 8, 2016·Molecular Neurodegeneration·Martina PigoniStefan F Lichtenthaler
Citations
Feb 1, 2018·Medicine·Maike SperkUjjwal Neogi
Jun 12, 2018·Journal of Internal Medicine·C FernandezO Melander
Feb 6, 2018·Scientific Reports·Anneli SundkvistBethany van Guelpen
Mar 2, 2018·Gut·Anneli SundkvistBethany Van Guelpen
Apr 30, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Robin MyteSophia Harlid
Jul 3, 2019·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kajsa BjörkmanCamilla Böckelman
Jan 9, 2020·Heart·Åsa K HedmanLars Lund
Nov 15, 2018·British Journal of Cancer·Jing QianHermann Brenner
Nov 16, 2018·Biochemia Medica·Milica StevanovicAleksandra Zeljkovic
Jun 27, 2019·Metabolic Syndrome and Related Disorders·Muni RubensEmir Veledar
Aug 15, 2019·Cancers·Yea Eun KangBon Seok Koo
Sep 13, 2020·Journal of Gastrointestinal Cancer·Ana FloreaElizabeth T Jacobs
Jul 1, 2020·Frontiers in Oncology·Yina YuJun Ye
Nov 19, 2020·Journal of Lipid Research·Carlota OleagaSergio Fazio
Dec 3, 2020·Critical Reviews in Oncology/hematology·Nathalie MichelsInge Huybrechts
Jan 25, 2021·Acta Paediatrica·Per SwärdMagnus K Karlsson
Dec 19, 2020·Frontiers in Immunology·Mohamed Abu-FarhaJehad Abubaker
Jan 12, 2021·Journal of Lipid Research·Carlota OleagaSergio Fazio
Mar 6, 2021·Scientific Reports·Sophia HarlidBethany Van Guelpen
Jul 3, 2021·Clinics and Research in Hepatology and Gastroenterology·Huadong WuBaojun Zhou
Nov 24, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Zhao-Yan LiuHui-Lian Zhu