The metabolism and n-6/n-3 ratio of essential fatty acids in rats: effect of dietary arachidonic acid and a mixture of sesame lignans (sesamin and episesamin)

Lipids
Rumi Umeda-SawadaOsamu Igarashi

Abstract

In this study, we examined the effect of dietary arachidonic acid (AA) and sesame lignans on the content and n-6/n-3 ratio of polyunsaturated fatty acid (PUFA) in rat liver and the concentrations of triglyceride (TG) and ketone bodies in serum. For 4 wk, rats were fed two types of dietary oils: (i) the control oil diet groups (CO and COS): soybean oil/perilla oil = 5:1, and (ii) the AA-rich oil group (AO and AOS): AA ethyl esters/palm oil/perilla oil = 2:2:1, with (COS and AOS) or without (CO and AO) 0.5% (w/w) of sesame lignans. Dietary AA and sesame lignans significantly affected hepatic PUFA metabolism. AA content and n-6/n-3 ratio in the liver were significantly increased in the AO group, despite the dietary total of n-6 PUFA being the same in all groups, while AOS diet reduced AA content and n-6/n-3 ratio to a level similar to the CO and COS groups. These results suggest that (i) dietary AA considerably affects the hepatic profile and n-6/n-3 ratio of PUFA, and (ii) dietary sesame lignans reduce AA content and n-6/n-3 ratio in the liver. In the AO group, the concentration of acetoacetate was significantly increased, but the ratio of beta-hydroxybutyrate/acetoacetate was decreased. On the other hand, the AO diet increased t...Continue Reading

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Citations

Oct 19, 2007·Critical Reviews in Food Science and Nutrition·Mitsuo Namiki
Mar 14, 2014·Journal of Experimental Botany·Mathias PribilDario Leister
Oct 2, 2001·Bioscience, Biotechnology, and Biochemistry·N NakanoH Yoshizumi
Sep 18, 2013·The World Journal of Men's Health·Zahra AbbasiHasan Morovvati
Apr 20, 2007·The Cochrane Database of Systematic Reviews·L DuleyJ F King
Nov 7, 2019·The Cochrane Database of Systematic Reviews·Lelia DuleyLisa M Askie

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