The metabolism of 1-phenyl-2-(N-methyl-N-benzylamino)propane (benzphetamine) and 1-phenyl-2-(N-methyl-N-furfurylamino)propane (furfenorex) in man

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
T Inoue, S Suzuki

Abstract

The metabolic fate of 1-phenyl-2-(N-methyl-N-benzylamino)propane (benzphetamine) and 1-phenyl-2-(N-methyl-N-furfurylamino)propane (furfenorex) in healthy volunteers has been investigated. Nine metabolites with traces of the unchanged drug were detected in human urine after oral administration of benzphetamine, and five metabolites were found following administration of furfenorex. The major metabolites were 1-(p-hydroxyphenyl)-2-(N-benzylamino)propane for benzphetamine and 1-phenyl-2-(N-methyl-N-gamma-valerolactonylamino)propane for furfenorex. In both cases, methamphetamine, amphetamine and their hydroxylated metabolites were also excreted as minor metabolites. Identified metabolites excreted in three days after administration of benzphetamine accounted for 30-44% of the dose and those excreted after administration of furfenorex, 31-46%.

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Citations

Jun 28, 1996·Forensic Science International : Synergy·S Seta
Feb 1, 1997·Pharmacology, Biochemistry, and Behavior·R YoungR A Glennon
Jan 25, 2003·Journal of Biochemical and Biophysical Methods·Ju-Tsung Liu, Ray H Liu
Jun 29, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·R KikuraS Kojima
Mar 10, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·M SatoH Nagase
May 25, 2002·Journal of Occupational and Environmental Medicine·John T Cody
Jul 15, 2009·Journal of Molecular Graphics & Modelling·Weihua LiSaburo Neya
Aug 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T Inoue, S Suzuki

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