The metabolism of 7-ethoxycoumarin and 7-hydroxycoumarin by rat and hairless mouse skin strips

Biochemical Pharmacology
S J MoloneyJ W Bridges

Abstract

The metabolism of 7-ethoxycoumarin and 7-hydroxycoumarin was studied in rat and hairless mouse skin strips. These preparations supported de-ethylation, sulphation and glucuronidation reactions. The de-ethylation reaction was inducible in both species by pretreatment with either 5,6-benzoflavone or 3-methylcholanthrene. The hairless mouse strips exhibited a greater basal de-ethylase activity than rat strips, although the latter was the more responsive to inducers. Accompanying the increase in de-ethylation activity was a change in the pattern of metabolites, with a large increase in the percentage of the unconjugated metabolite. When 7-hydroxycoumarin was employed as the primary substrate the glucuronide was the major metabolite formed by strips from both species. The glucuronidation and sulphation activities were unchanged by 3-methylcholanthrene pretreatment.

References

Feb 1, 1977·Biochemical Pharmacology·G J MulderJ R Gillette
Jul 1, 1972·Hoppe-Seyler's Zeitschrift für physiologische Chemie·V Ullrich, P Weber
Dec 15, 1982·Biochemical Pharmacology·S J MoloneyJ W Bridges
Apr 23, 1962·Biochimica Et Biophysica Acta·G J DUTTON, I H STEVENSON

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Citations

Dec 15, 1982·Biochemical Pharmacology·S J MoloneyJ W Bridges
Apr 27, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Carine JacquesDaniel Zalko
Jan 1, 1988·Annals of the New York Academy of Sciences·J Kao
Jan 1, 1990·Drug Metabolism Reviews·J Kao, M P Carver

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