The metabolism of [75Se]selenite in patients with short bowel syndrome

JPEN. Journal of Parenteral and Enteral Nutrition
T RannemS Jarnum

Abstract

Patients on home parenteral nutrition (HPN) require significantly higher amounts of selenium compared with controls. The purpose of the present study was to investigate if selenium deficiency of patients with short bowel syndrome is caused by selenium malabsorption or by excessive intestinal or renal loss. The metabolism of [75Se]selenite was investigated in eight selenium-depleted short bowel patients on HPN and in six control subjects. The isotope was given orally, and in a subsequent study as bolus injection or as 12-hour IV infusion. The fractional intestinal absorption of selenium was significantly reduced in the patients (2% to 58%, median 20%) when compared with the reference group (79% to 91%, median 82%) (p < .001). Within the group of patients we found a positive significant correlation between fractional selenium absorption and the length of the remaining small intestine (r = 0.95, p < .05). After parenteral [75Se]selenite administration, the patients showed a significantly higher fecal loss and a significantly reduced urinary excretion of 75Se when compared with the controls. Bolus injection vs 12-hour infusion of [75Se]selenite did not affect the cumulative fecal or urinary 75Se excretion in the HPN patients. Reduc...Continue Reading

References

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Citations

Jul 3, 1998·Gastroenterology Clinics of North America·L Howard, N Hassan
Dec 4, 2003·Best Practice & Research. Clinical Gastroenterology·Jon A Vanderhoof, Rosemary J Young
Jul 14, 2006·Gut·J NightingaleUNKNOWN Small Bowel and Nutrition Committee of the British Society of Gastroenterology
Mar 14, 2013·Current Medical Research and Opinion·Steven HofstetterJacob Willet
Apr 14, 2012·Journal of Pediatric Surgery·Sathyaprasad C Burjonrappa, Malki Miller
Jul 27, 2001·The Journal of International Medical Research·H KajiyamaS Kohno
Aug 10, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Imad F BtaicheKathleen B Welch
Apr 4, 2014·Inflammatory Bowel Diseases·Bodo Speckmann, Holger Steinbrenner
Jan 31, 2002·World Journal of Gastroenterology : WJG·J M Nightingale
Oct 20, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Ji Young LeeHan-Suk Kim
Oct 20, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Gilberto Fabian Hurtado-Torres

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