The metabolism of labeled parathyroid hormone. III. Studies in rats.

Calcified Tissue Research
W F NeumanK Lane

Abstract

A series of experiments indicated that 125I-parathyroid hormone administered to the rat i.v. was deposited very rapidly in three organ systems only, bone, kidney and the liver. As indicated by increasing solubility in trichloracetic acid, the hormone seemed to be rapidly metabolized at the sites of deposition. The experiments were in part repeated employing quantitative extraction and gel filtration procedures. It was found that intact hormone predominated (82%) in the circulation but was cleared very rapidly: 91, 97, and 99% having left by 10, 30 and 60 minutes respectively after injection. The intact hormone was found at 10 minutes to be principally in kidney, bone, and liver. Although there was evidence of fragmentation preferentially to polypeptides of molecular weights of 6000, 4500 and 2500 these cannot be claimed to represent real molecular entities. By one hour, only a few per cent of the injected hormone remained intact, the bulk having been degraded to fragments of small molecular weight.

References

Sep 17, 1975·Calcified Tissue Research·W F NeumanK Lane
Sep 17, 1975·Calcified Tissue Research·W F NeumanG W Casarett
Sep 17, 1975·Calcified Tissue Research·W F NeumanP J Sammon
Apr 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·M J IzzoW F Bale
Mar 20, 1968·Archives of Biochemistry and Biophysics·H F De LucaP F Neville

❮ Previous
Next ❯

Citations

Sep 17, 1975·Calcified Tissue Research·W F NeumanP J Sammon
Sep 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M DuquenneJ Leclere
Mar 1, 1984·The American Journal of Physiology·P D'Amour, P M Huet
Sep 1, 1981·The American Journal of Physiology·P D'AmourM Rosenblatt
Sep 17, 1975·Calcified Tissue Research·W F NeumanG W Casarett
Sep 17, 1975·Calcified Tissue Research·M W NeumanK Lane
Aug 24, 1979·Calcified Tissue International·M W NeumanK Lane
Sep 17, 1975·Calcified Tissue Research·W F NeumanK Lane
Aug 1, 1978·Metabolism: Clinical and Experimental·S B OldhamF R Singer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.