The metabolism of labeled parathyroid hormone. V. Collected biological studies.

Calcified Tissue Research
W F NeumanP J Sammon

Abstract

Biologically active 125I-labeled parathyroid hormone (125I-PTH) was used in a series of studies in dogs and chickens designed to confirm and augment earlier studies in rats. As in rats, a three exponential equation was required to describe disappearance of 125I-PTH from the blood in the dog. The first two "half-lives" (1.8 and 7 min) accounted for the bulk of the dose. Also as in rats, deposition of apparently intact hormone took place rapidly in kidney, liver and bone in both the dog and the chicken. Degradation occurred very rapidly in all three target organs. Three labeled hormones of different biological activities were compared in the rat. Inactive, oxidized hormone was rejected by the liver but showed markedly increased deposition in kidney and the higher the purity of the hormone the higher was its uptake by liver. Exploration of a wide range of dosages revealed few effects on distribution (smaller deposition in liver and kidney at highest dosages, 65 mug/rat). Fresh sera did not degrade hormone rapidly or extensively. There was no deposition of hormone in intestinal mucosa, marrow, and red cells. Nephrectomy increased deposition in liver and bone. Finally, the perfused liver was capable of extensive degradation of the h...Continue Reading

References

Sep 17, 1975·Calcified Tissue Research·W F NeumanK Lane
Sep 17, 1975·Calcified Tissue Research·W F NeumanK Lane
Sep 17, 1975·Calcified Tissue Research·W F NeumanG W Casarett
May 6, 1972·Lancet·L GalanteI MacIntyre
Aug 1, 1973·The Biochemical Journal·H S SutcliffeR Pilczyk
Jan 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J T PottsG D Aurbach
Feb 1, 1973·The Journal of Clinical Investigation·J M CanterburyE Reiss
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·F P Di BellaC D Arnaud
Feb 27, 1974·Biochemical and Biophysical Research Communications·C G Malbon, J E Zull
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·B KemperA Rich
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·D V CohnJ W Hamilton
Aug 2, 1972·Nature: New Biology·J F HabenerJ T Potts
Aug 17, 1973·Nature·L GalanteI MacIntyre
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J A FischerC D Arnaud
Nov 1, 1973·The American Journal of Physiology·M G BrunetteS Carriere
Jan 1, 1970·Endocrinology·T FujitaM Yoshikawa
Feb 1, 1972·The Journal of Clinical Endocrinology and Metabolism·T J MartinR A Melick
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·L M SherwoodW B Lundberg
Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J F HabenerJ T Potts
Oct 1, 1970·The Journal of Endocrinology·M de LuiseR A Melick
Jan 1, 1971·Poultry Science·A C Cox, S L Balloun
Jul 6, 1971·Biochemistry·H T KeutmannJ T Potts
May 1, 1971·The American Journal of Medicine·C D ArnaudE T Littledike

❮ Previous
Next ❯

Citations

Aug 24, 1979·Calcified Tissue International·M W NeumanK Lane
Mar 1, 1982·Calcified Tissue International·W F Neuman, M W Neuman
Mar 1, 1984·The American Journal of Physiology·P D'Amour, P M Huet
Sep 17, 1975·Calcified Tissue Research·M W NeumanK Lane
Nov 23, 1977·Pflügers Archiv : European journal of physiology·W H HunzikerJ A Fischer
Sep 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M DuquenneJ Leclere
Sep 17, 1975·Calcified Tissue Research·W F NeumanK Lane
Jun 7, 2007·The Journal of Clinical Endocrinology and Metabolism·F JosephW D Fraser
Nov 15, 1979·The New England Journal of Medicine·K J MartinE Slatopolsky
Mar 18, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Stan R UrsemAnnemieke C Heijboer
Dec 11, 1988·The American Journal of Physiology·F R BringhurstJ T Potts
Aug 1, 1978·Metabolism: Clinical and Experimental·S B OldhamF R Singer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.