The metabolism of labeled parathyroid hormone. VI. Effects of vitamin D status.

Calcified Tissue Research
M W NeumanK Lane

Abstract

Labeled 125I-PTH with full biological activity was utilized to investigate the interrelationship between vitamin D and parathyroid hormone (PTH) function. The distribution of labeled PTH was studied in rats and chickens on diets containing various amounts of vitamin D and calcium. The effects of vitamin D deficiency were found to be minor. There was a slightly delayed (10--30%) blood clearance of the hormone and a smaller deposition in the liver (20--30%) in the D-deficient animals. Deposition in bone and kidney appeared to be essentially normal. It is concluded that any failure of PTH to evoke a bone response in the deficient animal is not due to the failure of binding of hormone at the target organ.

References

Sep 17, 1975·Calcified Tissue Research·W F NeumanK Lane
Sep 17, 1975·Calcified Tissue Research·W F NeumanK Lane
Sep 17, 1975·Calcified Tissue Research·W F NeumanG W Casarett
Sep 17, 1975·Calcified Tissue Research·W F NeumanP J Sammon
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·I T BoyleH F DeLuca
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·M GarabedianI T Boyle
May 1, 1971·The American Journal of Medicine·J T PottsL J Deftos
Dec 1, 1966·The Journal of Clinical Investigation·C ArnaudC Anast
Dec 1, 1963·The Journal of Clinical Investigation·H RASMUSSENM VONSTEDINGK

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