The metabolism of nicotinamide in human liver cirrhosis: a study on N-methylnicotinamide and 2-pyridone-5-carboxamide production

The American Journal of Gastroenterology
R PumpoR Cuomo

Abstract

Nicotinamide methylation followed by urinary excretion of N-methylnicotinamide increases in cirrhotic patients, despite the derangement of the overall methylation processes in liver disease. The rise in N-methylnicotinamide could depend, at least in part, on a reduced transformation of this molecule into 2-pyridone-5-carboxamide. The aim of this study was to investigate this hypothesis. Serum and urinary levels (mean +/- SEM) of N-methylnicotinamide and urinary excretion of 2-pyridone-5-carboxamide were measured in 10 healthy controls and 10 patients with liver cirrhosis in basal conditions and after a nicotinamide oral load (1.5 mg/kg body weight). N-methylnicotinamide serum levels increased significantly (p < 0.01) in cirrhotic patients compared to controls, both as basal values (0.43 +/- 0.07 nmol/ml; 0.15 +/- 0.01) and as area under the curve 5 h after a nicotinamide load (cirrhotics: 562.4 +/- 50.5 nmol/ml x min; controls: 314.4 +/- 23.8). Twenty-four-hour urinary excretion of N-methylnicotinamide and 2-pyridone-5-carboxamide was also significantly (p < 0.05) increased in cirrhotic patients versus controls, both in basal conditions (N-methylnicotinamide: 82.0 +/- 8.4 micromol, 48.8 +/- 4.8; 2-pyridone-5-carboxamide: 129.3 ...Continue Reading

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Citations

Dec 5, 2009·World Journal of Gastroenterology : WJG·Shi-Sheng ZhouZheng-Ning Li
May 20, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Kazuo OdaKin-Ya Sohda
Apr 11, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ewa M SlominskaJulian Swierczynski
Mar 1, 2018·Pharmacological Reviews·Fabian MüllerMartin F Fromm
Jan 8, 2020·Journal of Biochemical and Molecular Toxicology·Rakhee J MistryRichard B Parsons
Jan 22, 2019·Nucleosides, Nucleotides & Nucleic Acids·Paulina MierzejewskaEwa M Slominska
Mar 25, 2009·Pharmacological Reports : PR·Cezary WatałaStefan Chłopicki
Oct 23, 2012·Clinical Pharmacology and Therapeutics·M F Fromm
Feb 23, 2011·Radiation Research·Congju ChenTruman R Brown
Jan 3, 2021·Molecular Neurobiology·Altin KocinajRichard B Parsons
Apr 19, 2005·Chemical Research in Toxicology·Nigel J WatersJeremy K Nicholson
Sep 12, 2014·Journal of Proteome Research·Xiaoyang ZhuYulan Wang
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Oct 20, 2009·Neurochemistry International·Tamara KuchmerovskaArkady Klimenko

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