PMID: 8586836Nov 1, 1995Paper

The metabolism of platelet-activating factor in severe and cerebral malaria

The Journal of Infection
T M DavisT K Anh

Abstract

In order to examine the effects of platelet-activating factor (PAF) in complicated Plasmodium falciparum infections, plasma concentrations of lyso-PAF, stable metabolite and principal precursor of PAF, were measured in 25 Vietnamese adults with severe malaria. The concentration of PAF in the cerebrospinal fluid (CSF) was determined in a sub-group of 23 comatose patients and, together with that of lyso-PAF, in the plasma of 20 patients on recovery of consciousness. The concentration of lyso-PAF in the plasma was depressed on admission to hospital (median [range]; 21 [8-143] vs. 293 [215-410] ng/ml in 10 controls; P < 0.001). There was, however, no change in plasma activity of acetylhydrolase which converts PAF to lyso-PAF (P > 0.01 vs. controls) while simultaneous reduction in the concentration of lipoproteins associated with lyso-PAF were less than those of lyso-PAF per se in the plasma. The plasma concentration of lyso-PAF on admission was associated with parasitaemia and the concentration of serum triglycerides (rs = -0.42, P = 0.04 in each case), the latter being consistent with hepatic effects of PAF reported in previous studies. CSF concentrations of PAF on admission were low (2.3 [0.5-7.7] vs. 0.9 [0-2.5] ng/ml after reco...Continue Reading

References

Jan 1, 1992·Advances in Parasitology·N J White, M Ho
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Apr 1, 1991·Resuscitation·G SchlagS Hallström
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Aug 1, 1993·International Journal for Parasitology·T M DavisC D Smith
May 1, 1993·The Journal of Infection·T M DavisR R Taylor

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Citations

Sep 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·T M DavisN J White
Apr 16, 2014·Malaria Journal·Julie LothariusTimothy Wells

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