The metabolites citrate, myo-inositol, and spermine are potential age-independent markers of prostate cancer in human expressed prostatic secretions

The Prostate
Natalie J SerkovaE David Crawford

Abstract

Due to specific physiological functions, prostatic tissues and fluids have unique metabolic profiles. In this study, proton nuclear magnetic resonance spectroscopy ((1)H-NMRS) is used to assess potential metabolic markers of prostate cancer (PCa) in human expressed prostatic secretions (EPS). Metabolic profiles of EPS from 52 men with PCa and from 26 healthy controls were analyzed using quantitative (1)H-NMRS. The metabolites quantified included citrate, spermine, myo-inositol, lactate, alanine, phosphocholine, glutamine, acetate, and hydroxybutyrate. Logistic regression (LR) was used to model the risk of PCa based on metabolite concentrations while adjusting for age. The average age of the EPS donors with PCa was 58.0+/-7.0 years and 52.2+/-12.1 for the healthy donors. The median Gleason score for the men with PCa was 7 (range 5-9). The LR models indicated that the absolute concentrations of citrate, myo-inositol, and spermine were highly predictive of PCa and inversely related to the risk of PCa. The areas under the receiver operating characteristic curves (AUROC) for citrate, myo-inositol and spermine were 0.89, 0.87, and 0.79, respectively. At 90% sensitivity, these metabolites had specificities of 74%, 51%, and 34%, respec...Continue Reading

References

Mar 6, 1999·The Prostate·L C CostelloP Narayan
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·R J GilliesB Van Der Sanden
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·J L EvelhochH M Swartz
Jul 19, 2001·Journal of the National Cancer Institute·M S PepeY Yasui
Dec 3, 2002·Annals of Internal Medicine·Russell Harris, Kathleen N Lohr
May 8, 2003·Journal of the National Cancer Institute·Michael W Kattan
Oct 15, 2003·Biostatistics·Ruth EtzioniPeter H Gann
May 28, 2004·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Jul 2, 2004·Nature Reviews. Cancer·Julian L Griffin, John P Shockcor
Jul 29, 2004·Clinical Prostate Cancer·Shandra S Wilson, E David Crawford
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sven GottschalkNatalie J Serkova
Apr 27, 2005·Lancet·E David Crawford
Mar 2, 2006·BJU International·John M Fitzpatrick
Oct 3, 2006·Expert Review of Molecular Diagnostics·Natalie J Serkova, Claus U Niemann
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

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Citations

Jul 2, 2008·Prostate Cancer and Prostatic Diseases·L C Costello, R B Franklin
Apr 25, 2012·The Journal of Biological Chemistry·Miroslava Cuperlovic-CulfMohamed Touaibia
Apr 8, 2009·Genome Medicine·Que N Van, Timothy D Veenstra
Mar 8, 2012·Bioanalysis·Thomas M O'Connell
Feb 18, 2010·Biomarkers in Medicine·Andrea L Merz, Natalie J Serkova
Apr 22, 2010·Biomarkers in Medicine·G A Nagana Gowda
Aug 30, 2013·BioMed Research International·Diego F Gomez-CasatiMaría V Busi
Apr 23, 2011·Bioanalysis·Renata BujakMichał Jan Markuszewski
Jul 6, 2014·The Analyst·Patricia ZaragozáRamón Martínez-Máñez
Sep 13, 2008·Expert Review of Molecular Diagnostics·G A Nagana GowdaDaniel Raftery
Mar 1, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·Iola F Duarte, Ana M Gil
Sep 21, 2011·Urologic Oncology·Bruce J Trock
Sep 21, 2011·Urologic Oncology·Matthew E HyndmanTrinity J Bivalacqua
Jul 17, 2010·The International Journal of Biochemistry & Cell Biology·Orla TeahanHector C Keun
Dec 4, 2015·British Journal of Cancer·Guro F GiskeødegårdMay-Britt Tessem
Mar 10, 2009·Journal of Cellular and Molecular Medicine·Natalie J SerkovaDouglas J Kominsky
Oct 23, 2009·Journal of Cellular and Molecular Medicine·Gareth CatchpoleSteffen Weikert
Jul 6, 2013·NMR in Biomedicine·Virendra KumarNaranamangalam R Jagannathan
Sep 30, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Isabell K SteinseiferArend Heerschap
Aug 2, 2013·NMR in Biomedicine·M Albert ThomasSteven S Raman
Feb 13, 2014·NMR in Biomedicine·Meer BasharatGeoffrey S Payne
Jan 28, 2010·Analytica Chimica Acta·Rasmus MadsenJohan Trygg
May 28, 2015·Annals of the New York Academy of Sciences·Stefano Cacciatore, Massimo Loda
Jun 30, 2012·The International Journal of Biochemistry & Cell Biology·Pratima TripathiAyyalusamy Ramamoorthy
Nov 13, 2014·Journal of Proteome Research·Eric Chun Yong ChanKesavan Esuvaranathan
Mar 8, 2011·Korean journal of urology·Matthew J RobertsRobert A Gardiner
Mar 10, 2016·Expert Review of Molecular Diagnostics·Deepak KumarKavindra Nath
May 21, 2016·The Prostate·Deepak KumarSatya Narain Sankhwar
Jul 19, 2016·Metabolomics : Official Journal of the Metabolomic Society·Basetti MadhuJohn R Griffiths
Aug 25, 2016·Journal of Magnetic Resonance Imaging : JMRI·Jan WeisHåkan Ahlström
Aug 29, 2016·Translational Oncology·Ana Rita LimaPaula Guedes de Pinho
Jan 1, 2010·Cancers·Raymond A ClarkeRobert A Gardiner
Mar 16, 2019·Pharmaceutics·Tânia F G G CovaSandra C C Nunes
May 19, 2011·Nature Reviews. Urology·Elita M DeFeoLeo L Cheng

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