The metabolomics of necrotising enterocolitis in preterm babies: an exploratory study

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Amy WilcockSuresh Victor

Abstract

No single diagnostic investigation is currently available for necrotising enterocolitis (NEC). We implemented a novel, untargeted, exploratory study to determine whether metabolomics can reveal early biomarker(s) of NEC. The effect of gestational age on the metabolome was also investigated. Two serum samples were obtained from 12 preterm babies (born <30 weeks gestation) and eight term controls: sample "A" at ≤1 week of age and sample "B" once fully fed. Samples were subjected to gas chromatography-mass spectrometry. Metabolomic data was analysed by principal component analysis (PCA), univariate and network analysis. Sixteen metabolite features significantly differed when B samples were compared between preterm babies who subsequently developed NEC and preterm/term controls (p value <0.05). Of these seven metabolites were linked to up-regulation of IL-1β. Significant differences in 54 metabolite features (p value <0.05) were observed between preterm and term metabolomes. Of these, 12 metabolite features were linked to one network involved in carbohydrate/lipid metabolism (p = 1 × 10(-30)). Metabolomic differences were observed in preterm babies at risk of NEC. However, sample sizes were insufficient to confidently identify a bi...Continue Reading

References

Feb 29, 2000·Journal of Pediatric Surgery·C E ShinB W Warner
Aug 10, 2000·Nature·R AlbertA L Barabasi
Dec 13, 2000·The Journal of Pediatrics·R M BeckerJ M Rhoads
Jan 10, 2001·The Journal of Pediatrics·S S RabinowitzE Kornecki
Mar 6, 2004·Seminars in Neonatology : SN·Jane S Lee, Richard A Polin
Sep 2, 2005·Nature·Steve E CalvanoUNKNOWN Inflamm and Host Response to Injury Large Scale Collab. Res. Program
Sep 21, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·Clare M ReesSimon Eaton
Sep 21, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shelley S Tworoger, Susan E Hankinson
Mar 19, 2008·Seminars in Perinatology·Patricia W LinBarbara J Stoll
Feb 1, 2011·Early Human Development·Marcelo H Decaro, Nestor E Vain
Nov 15, 2011·Journal of Pediatric Surgery·Ahmet GuvenAhmet Korkmaz
Feb 22, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Serafina PerroneGiuseppe Buonocore
May 16, 2012·Genome Medicine·Farshad FarshidfarOliver F Bathe
Jul 10, 2012·Pediatrics and Neonatology·Shu-Fen WuHung-Chih Lin
Mar 8, 2013·The Journal of Surgical Research·Sadik YurttutanUgur Dilmen
May 25, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hsiang-Yu LinHung-Chih Lin
Dec 18, 2013·Bioinformatics·Andreas KrämerStuart Tugendreich

❮ Previous
Next ❯

Citations

Jul 13, 2016·Expert Review of Molecular Diagnostics·Angelica DessìVassilios Fanos
Aug 2, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Bhawan Deep GargAnju Bansal
Mar 7, 2021·Life·Alessandra CosciaDiego Giampietro Peroni
Apr 27, 2021·Expert Review of Proteomics·Lauren C BeckChristopher J Stewart
Oct 10, 2021·Acta Paediatrica·Victoria L Renwick, Christopher J Stewart

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.