The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region

Brain Research
Walter FrancesconiPietro Paolo Sanna

Abstract

Selective antagonists of the metabotropic receptors 1 (mGluR1), +/-2-methyl-4-carboxyphenylglycine (LY367385), and mGluR5, 2-methyl-6-(phenylethynyl)-pyridine (MPEP), were used to investigate the role of group I metabotropic receptors in late-phase long-term potentiation (L-LTP) at Schaffer collateral/commissural fiber-CA1 synapses in rat hippocampal slices. L-LTP was induced with three trains of tetanization of 1 s duration at 100 Hz separated by 10-min intervals. Neither LY367385 nor MPEP affected basal synaptic responses at the doses used (200 and 10 microM, respectively) and only the mGluR5 inhibitor MPEP blocked L-LTP. However, in agreement with previous mouse mutant studies, we found that both LY367385 and MPEP inhibited the induction of an LTP obtained with a single train of tetanization of 1 s duration at 100 Hz. MPEP's ability to disrupt L-LTP was not due to an effect on NMDA responses since it did not affect pharmacologically isolated N-methyl-D-aspartate (NMDA) excitatory postsynaptic potentials (EPSPs). However, MPEP prevented the increased phosphorylation in dendrites of p70 S6 kinase (p70(S6K)) at Thr3889, a major regulator of translation required for the induction of protein synthesis-dependent forms of LTP.

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Citations

Oct 24, 2007·Molecular Neurobiology·Brad A GrueterDanny G Winder
Mar 20, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer E AyalaP Jeffrey Conn
Aug 16, 2005·Genes, Brain, and Behavior·P W Vanderklish, G M Edelman
Nov 25, 2011·Journal of Neurophysiology·Peng Zhang, John E Lisman
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Armaz AschrafiPeter W Vanderklish
Dec 22, 2009·Advances in Medical Sciences·A Nadlewska, R J Wiśniewska
Jun 6, 2007·Neurobiology of Learning and Memory·A SimonyiT R Schachtman
Mar 28, 2008·The European Journal of Neuroscience·Sergey Neyman, Denise Manahan-Vaughan
Jul 16, 2013·Pharmacology, Biochemistry, and Behavior·Arlene Martínez-RiveraCarmen S Maldonado-Vlaar
May 31, 2011·Neuropharmacology·Paige N Vinson, P Jeffrey Conn
Jun 4, 2020·International Journal of Molecular Sciences·Roberta Gualdani, Philippe Gailly
Mar 31, 2018·Frontiers in Molecular Neuroscience·Regina Dahlhaus

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