The metaphase-to-anaphase transition: avoiding a mid-life crisis

Current Opinion in Cell Biology
O Cohen-Fix, D Koshland

Abstract

The metaphase-to-anaphase transition is a highly regulated process, which is governed by the activity of the anaphase-promoting complex (APC). The APC promotes the degradation of several proteins, including mitotic cyclins and newly identified anaphase inhibitors. Several discoveries made this year shed invaluable light on the regulation of APC activation and its substrate specificity.

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·F Spencer, P Hieter
Aug 9, 1991·Cell·R Li, A W Murray
Jan 1, 1991·Cold Spring Harbor Symposia on Quantitative Biology·R S SikorskiP Hieter
Jan 10, 1991·Nature·M GlotzerM W Kirschner
May 1, 1991·Trends in Biochemical Sciences·M Goebl, M Yanagida
Jan 1, 1974·Cold Spring Harbor Symposia on Quantitative Biology·B Byers, L Goetsch
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·S Lahav-BaratzA Hershko
Sep 1, 1993·The Journal of Cell Biology·G J Gorbsky, W A Ricketts
Mar 1, 1993·Molecular and Cellular Biology·H M van der Velden, M J Lohka
Jun 1, 1993·Genes & Development·N KinoshitaM Yanagida
Apr 1, 1993·Current Opinion in Cell Biology·K Nasmyth
Aug 1, 1996·Nature·D Zhang, R B Nicklas
Oct 11, 1996·Science·Y Li, R Benezra
Aug 1, 1996·Molecular Biology of the Cell·F Pangilinan, F Spencer
Nov 15, 1996·Science·J M PetersM W Kirschner
Oct 1, 1996·Trends in Genetics : TIG·K Nasmyth
Dec 1, 1996·Current Opinion in Cell Biology·A D Rudner, A W Murray
Dec 6, 1996·Science·R W KingM W Kirschner
Apr 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S E Bickel, T L Orr-Weaver
Jun 1, 1997·Molecular Biology of the Cell·V GuacciD Koshland
Jul 25, 1997·Science·A F StraightA W Murray

❮ Previous
Next ❯

Citations

Jan 23, 1999·Current Opinion in Cell Biology·S Biggins, A W Murray
Nov 5, 1998·Molecular Biology of the Cell·X S YeS A Osmani
Jun 29, 2000·Annual Review of Biochemistry·W C EarnshawS H Kaufmann
May 7, 1999·Environmental Health Perspectives·R E ShackelfordR S Paules
Jun 4, 1998·Current Opinion in Genetics & Development·T Weinert
Nov 16, 2011·Cellular and Molecular Life Sciences : CMLS·Karen FinnMuriel Grenon
May 14, 1999·Current Opinion in Genetics & Development·S Biggins, A W Murray
Jan 7, 2000·Experimental Cell Research·P K YeungJ T Wong
Feb 2, 1999·Experimental Cell Research·J M CraigP Vagnarelli
Aug 17, 1999·Seminars in Cancer Biology·G A Pihan, S J Doxsey
Oct 24, 1998·The Journal of Cell Biology·R H ChenA W Murray
Aug 30, 2003·Oncogene·William H McBrideFrank Pajonk
Nov 7, 1998·The Journal of Biological Chemistry·C D ScatenaJ A Pietenpol
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R M DouglasG G Haddad
Jun 22, 1999·Molecular and Cellular Biology·G OshiroJ J Li
Jan 5, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G J GorbskyL M Topper
Aug 10, 2000·Trends in Cell Biology·K J Dej, T L Orr-Weaver

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.