The metastatic potential of seminomatous germ cell tumours is associated with a specific microRNA pattern.

Andrology
Simone ErnstJulia Heinzelbecker

Abstract

Seminomatous germ cell tumours (SGCT) are the most frequent malignancy in young men. Reliable prognostic biomarkers for the prediction of metastasis at diagnosis and the risk of relapse in clinical stage I (CSI) are lacking. Adjuvant therapies carry a risk of overtreatment, whereas salvage therapies have a risk of high toxicities. Thus, the identification of reliable prognostic biomarkers is highly desirable to identify patients who will benefit from early adjuvant treatment. MicroRNAs (miRNAs) regulate tumour development and progression, and their potential as biomarkers has already been proven in a variety of malignancies. The aim of our study was to define a specific miRNA expression pattern that discriminates metastatic from non-metastatic primary SGCT. Total RNA was isolated from 24 formalin-fixed paraffin-embedded (FFPE) primary SGCT tumours (10 non-metastatic, five metachronously and nine synchronously metastatic) and from 10 normal testicular tissue samples. Microarray analysis was performed for global miRNA expression profiling. The results were validated by quantitative real-time polymerase chain reaction (qRT-PCR). Statistical analysis was performed using SPSS. Microarray analyses revealed a specific miRNA pattern th...Continue Reading

References

Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Jan 2, 2009·Urologic Oncology·Annika SchaeferKlaus Jung
Oct 20, 2009·Seminars in Oncology·Brandon Hayes-Lattin, Craig R Nichols
Mar 25, 2010·Cancer Research·Roger D PalmerUNKNOWN Children's Cancer and Leukaemia Group
Dec 22, 2010·American Journal of Clinical Pathology·Matthew J MurrayNicholas Coleman
Jan 25, 2011·The Lancet Oncology·Steven Christopher SmithDan Theodorescu
Mar 16, 2012·Endocrine-related Cancer·Guy Wayne NovotnyHenrik Leffers
Sep 1, 2012·Current Molecular Medicine·M J SchmittS Kreis
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hege S HaugnesSophie D Fosså
Oct 16, 2012·Virchows Archiv : an International Journal of Pathology·Z BingJ E Tomaszewski
Jul 30, 2014·European Urology·Mette Saksø MortensenGedske Daugaard
Apr 19, 2015·Journal of Ovarian Research·Yingying ZhouTing Shuang
Dec 15, 2015·Journal of Cancer Research and Clinical Oncology·Maria SchubertJoana Heinzelmann
Aug 9, 2016·European Urology·Klaus-Peter DieckmannGazanfer Belge
Aug 20, 2016·Oncotarget·Jian LiHuaizhi Wang
Mar 1, 2017·Pediatric Blood & Cancer·Archie BleyerRonald D Barr
Mar 16, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Klaus-Peter DieckmannGazanfer Belge

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