The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes.

Cellular and Molecular Life Sciences : CMLS
Zita NagyL Tora

Abstract

Histone acetyl transferases (HATs) play a crucial role in eukaryotes by regulating chromatin architecture and locus-specific transcription. The GCN5 HAT was identified as a subunit of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) multiprotein complex. Vertebrate cells express a second HAT, PCAF, that is 73% identical to GCN5. Here, we report the characterization of the mammalian ATAC (Ada-Two-A-Containing) complexes containing either GCN5 or PCAF in a mutually exclusive manner. In vitro ATAC complexes acetylate lysine 14 of histone H3. Moreover, ATAC- or SAGA-specific knock-down experiments suggest that both ATAC and SAGA are involved in the acetylation of histone H3K9 and K14 residues. Despite their catalytic similarities, SAGA and ATAC execute their coactivator functions on distinct sets of inducible target genes. Interestingly, ATAC strongly influences the global phosphorylation level of histone H3S10, suggesting that in mammalian cells a cross-talk exists linking ATAC function to H3S10 phosphorylation.

References

Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·R E SobelC D Allis
Jul 23, 1998·Cell·V V OgryzkoY Nakatani
Feb 20, 1999·The Journal of Biological Chemistry·P A GrantJ L Workman
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·D E Sterner, S L Berger
Mar 16, 2001·Current Opinion in Genetics & Development·J J Hayes, J C Hansen
Jun 8, 2001·Annual Review of Biochemistry·S Y RothC D Allis
Jan 5, 2002·The Journal of Biological Chemistry·Ramakrishnan BalasubramanianSong Tan
Apr 17, 2003·Molecular and Cellular Biology·Thomas KuschJerry L Workman
Jun 13, 2003·Trends in Genetics : TIG·Michael J CarrozzaJacques Côté
Jun 28, 2003·FEBS Letters·Alison L Clayton, Louis C Mahadevan
Feb 7, 2004·The EMBO Journal·Claire LeurentPatrick Schultz
Apr 22, 2004·Molecular Cell·Antigone KouskoutiIannis Talianidis
Apr 30, 2004·Human Molecular Genetics·Dominique HelmlingerDidier Devys
Aug 27, 2005·Cell·Dmitry K PokholokRichard A Young
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lyubov A LebedevaLàszlò Tora
Feb 14, 2006·Science·Michael Shogren-KnaakCraig L Peterson
Jul 25, 2006·Critical Reviews in Biochemistry and Molecular Biology·Mary C Thomas, Cheng-Ming Chiang
Feb 27, 2007·Cell·Tony Kouzarides
Feb 27, 2007·Cell·Bing LiJerry L Workman
Mar 17, 2007·Annual Review of Biochemistry·Mona D Shahbazian, Michael Grunstein
Mar 24, 2007·Nature Reviews. Molecular Cell Biology·Kenneth K Lee, Jerry L Workman
Jun 23, 2007·The Journal of Biological Chemistry·Barbora MalecováThomas Oelgeschläger

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Citations

Aug 28, 2012·Journal of Biochemistry·Mohankrishna Dalvoy VasudevaraoTapas K Kundu
Apr 3, 2012·Genes & Development·Kinga KamieniarzRobert Schneider
Mar 20, 2012·Genes & Development·Gianpiero SpedaleW W M Pim Pijnappel
Sep 21, 2013·The Journal of Clinical Investigation·Kim RavnskjaerMarc Montminy
Jul 22, 2011·Epigenetics & Chromatin·Irina A MaksakovaMatthew C Lorincz
Jun 23, 2012·PLoS Genetics·Kin Chung LamAsifa Akhtar
Aug 12, 2014·Epigenomics·Li Wang, Sharon Y R Dent
May 21, 2014·ELife·Tomasz ChelmickiAsifa Akhtar
Sep 17, 2013·Journal of Integrative Plant Biology·Lianyu YuanKeqiang Wu
Jun 20, 2014·Alcoholism, Clinical and Experimental Research·Andrey Finegersh, Gregg E Homanics
Dec 14, 2011·The Biochemical Journal·Gráinne BarkessKatherine L West
Oct 23, 2016·Journal of Molecular Biology·Calley L HirschSharon Y R Dent
Oct 25, 2016·Journal of Proteomics·Jeovanis GilSergio Encarnación-Guevara
Mar 10, 2016·Development·Emese GazdagGert Jan C Veenstra
Jul 12, 2018·Cell Cycle·V V PopovaD V Kopytova
Apr 15, 2015·Molecular and Cellular Biology·Petros PapadopoulosLàszlò Tora
Feb 11, 2015·Oncogene·A FarriaS Y R Dent
Jul 4, 2020·Experimental & Molecular Medicine·Youngseo CheonDaeyoup Lee
Jan 29, 2011·Cell Cycle·Abul B M M K IslamElizaveta V Benevolenskaya
Oct 24, 2017·Nature Communications·Wenyi MiXiaobing Shi
Mar 21, 2019·Journal of Cell Science·Tiina ViitaMaria K Vartiainen
Dec 2, 2020·Scientific Reports·Shao-An WangJan-Jong Hung
Aug 1, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Eliana F Torres-Zelada, Vikki M Weake
Sep 6, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Jose M Espinola-Lopez, Song Tan
Jan 15, 2021·Clinical Science·Md Ezazul HaqueDong-Kug Choi
Aug 3, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Dominique HelmlingerLászló Tora

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