PMID: 9426690Jan 14, 1998Paper

The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia

International Journal of Cancer. Journal International Du Cancer
Y HoriT Nobori

Abstract

Adult T-cell leukemia (ATL) is a retrovirus-associated leukemia with poor prognosis and often has deletions of the p16INK4a and p15INK4b genes on chromosome 9p21. The gene for methylthioadenosine phosphorylase (MTAP), a purine and methionine metabolic enzyme, resides approximately 100 Kb telomeric to the p16INK4a gene and is frequently co-deleted with the tumor suppressor gene in a variety of cancers. This enzyme deficiency can be exploited for selective chemotherapy with de novo purine synthesis inhibitors and/or methionine depletion. To determine whether ATL can be a candidate for selective chemotherapy based on genetic alterations on chromosome 9p21, we analyzed the MTAP gene in 41 samples from ATL patients (27 acute type and 14 chronic type ATL) and 3 cell lines established from ATL patients. Five samples from the acute type had deletions of the MTAP gene (4 total deletions and 1 partial deletion of exons 6-8). The MTAP gene was always co-deleted with p16INK4a. No deletion of the MTAP gene was detected in samples from the chronic type. Of 3 cell lines, 2 showed partial deletions of exons 5-8 of the MTAP gene, and 1 lost all exons. The p16INK4a gene was deleted in all cell lines. In conclusion, deletions of the MTAP gene wer...Continue Reading

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Citations

Mar 16, 2007·Expert Opinion on Emerging Drugs·Giorgio Vittorio Scagliotti, Giovanni Selvaggi
Apr 7, 2012·Journal of Dermatological Science·Xuejun Zhang
Jul 24, 2003·The American Journal of Pathology·Iris BehrmannAnja-Katrin Bosserhoff
Jun 1, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Peter J WildAnja Katrin Bosserhoff
Oct 4, 2005·Neurological Research·Kouichi WadaToshiki Yoshimine
Feb 9, 2011·Cancer Biology & Therapy·Joseph R BertinoMartin Lubin
Sep 3, 2011·The Journal of Molecular Diagnostics : JMD·Inês CrespoMaría Dolores Tabernero
Sep 14, 2016·Oncoimmunology·Frederik C HenrichAndreas Mackensen
Oct 28, 1998·Genes, Chromosomes & Cancer·R KumarK Hemminki
Jul 11, 2013·PloS One·Yuwaraj KadariyaWarren D Kruger
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hsuan-Ying HuangMarc Ladanyi
Oct 20, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Frauke BatailleAnja-Katrin Bosserhoff
Feb 9, 2005·Brain Tumor Pathology·Tsuyoshi SuzukiToshiki Yoshimine
Feb 9, 2005·Brain Tumor Pathology·Kouichi WadaToshiki Yoshimine
Jun 15, 2014·The Oncologist·Pashna N MunshiJoseph R Bertino

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