The MHC class I homolog of human cytomegalovirus is resistant to down-regulation mediated by the unique short region protein (US)2, US3, US6, and US11 gene products

The Journal of Immunology : Official Journal of the American Association of Immunologists
Boyoun ParkK Ahn

Abstract

Human CMV encodes four unique short region proteins (US), US2, US3, US6, and US11, each independently sufficient for causing the down-regulation of MHC class I molecules on the cell surface. This down-regulation allows infected cells to evade recognition by cytotoxic T cells but leaves them susceptible to NK cells, which lyse cells that lack class I molecules. Another human CMV-encoded protein, unique long region protein 18 (UL18), is an MHC class I homolog that might provide a mechanism for inhibiting the NK cell response. The sequence similarities between MHC class I molecules and UL18 along with the ability of UL18 to form trimeric complexes with beta(2)-microglobulin and peptides led to the hypothesis that if the US and UL18 gene products coexist temporally during infection, the US proteins might down-regulate UL18 molecules, similar to their action on MHC class I molecules. We show here that temporal expression of US and UL18 genes partially overlaps during infection. However, unlike MHC class I molecules, the MHC class I homolog, UL18, is fully resistant to the down-regulation associated with the US2, US3, US6, and US11 gene products. The specific effect of US proteins on MHC class I molecules, but not on UL18, represents...Continue Reading

References

Sep 1, 1990·Reviews of Infectious Diseases·M Ho
Jan 1, 1989·Annual Review of Immunology·A Townsend, H Bodmer
Jan 21, 1988·Nature·D Wiley
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·K AhnK Früh
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·T R JonesH L Ploegh
Feb 1, 1997·Immunological Reviews·L L LanierJ H Phillips
Apr 3, 1997·Nature·K Kärre, R M Welsh
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·P J LehnerP Cresswell
May 2, 1998·Science·H L Ploegh
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y JunK Ahn

❮ Previous
Next ❯

Citations

Aug 9, 2005·Pflügers Archiv : European journal of physiology·Sandra Loch, Robert Tampé
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia S WagnerAdnane Achour
Feb 25, 2009·Current Protocols in Immunology·Roberto Biassoni
Nov 2, 2019·Nature Reviews. Immunology·Richard BerryJamie Rossjohn
Oct 31, 2002·Nature Immunology·Jordan S OrangeJack L Strominger
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniele SaverinoErmanno Ciccone
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason L PetersenJoyce C Solheim
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yizhou ZouPeter Stastny
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark R WillsJ G Patrick Sissons
Oct 6, 2005·Journal of Leukocyte Biology·Alexandre IannelloAli Ahmad
Mar 29, 2012·Immunologic Research·Vanessa NoriegaDomenico Tortorella
Dec 17, 2015·The Journal of General Virology·Caleb CornabyBradford K Berges
Jan 23, 2018·Immunology·Kayla A HolderMichael D Grant
Aug 9, 2008·PLoS Pathogens·Youngkyun KimKwangseog Ahn
Jun 6, 2013·Molecular and Cellular Biochemistry·Roberta RizzoTiziana Bellini
Feb 22, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Virginie Prod'hommeGavin W G Wilkinson
May 30, 2014·Viruses·Patrick J Hanley, Catherine M Bollard
Jan 8, 2014·The Journal of General Virology·Sepehr SeirafianGavin W G Wilkinson
Jul 25, 2018·Current Protocols in Immunology·Roberto Biassoni, Mauro S Malnati
Sep 27, 2005·Immunological Reviews·Tom A M GroothuisJacques J Neefjes
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Virginie Prod'hommePeter Tomasec
Apr 30, 2017·Virus Genes·Günther SchönrichMartin J Raftery
Jul 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Zhiru Yang, Pamela J Bjorkman
Oct 18, 2005·The Journal of General Virology·Cora GriffinPeter Tomasec
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Massimo MaffeiErmanno Ciccone
Sep 28, 2007·Journal of Leukocyte Biology·Claudia S WagnerBenedict J Chambers
Dec 31, 2003·Biochemical and Biophysical Research Communications·Gyu Man ParkKwangseog Ahn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.