The MIA pathway: a tight bond between protein transport and oxidative folding in mitochondria

Biochimica Et Biophysica Acta
Diana StojanovskiAgnieszka Chacinska

Abstract

Many newly synthesized proteins obtain disulfide bonds in the bacterial periplasm, the endoplasmic reticulum (ER) and the mitochondrial intermembrane space. The acquisition of disulfide bonds is critical for the folding, assembly and activity of these proteins. Spontaneous oxidation of thiol groups is inefficient in vivo, therefore cells have developed machineries that catalyse the oxidation of substrate proteins. The identification of the machinery that mediates this process in the intermembrane space of mitochondria, known as MIA (mitochondrial intermembrane space assembly), provided a unique mechanism of protein transport. The MIA machinery introduces disulfide bonds into incoming intermembrane space precursors and thus tightly couples the process of precursor translocation to precursor oxidation. We discuss our current understanding of the MIA pathway and the mechanisms that oversee thiol-exchange reactions in mitochondria.

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Citations

Sep 18, 2012·Molecular & Cellular Proteomics : MCP·F-Nora VögtleChris Meisinger
Mar 20, 2013·Molecular and Cellular Biology·Piotr BragoszewskiAgnieszka Chacinska
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