The microbial and danger signals that activate Nod-like receptors

Cytokine
Szilvia BenkoStephen E Girardin

Abstract

Nod-like receptors (NLRs) are a family of intracellular sensors that play key roles in innate immunity and inflammation. While some NLRs, including Nod1, Nod2, NAIP and IPAF, detect conserved bacterial molecular signatures from within the host cytosol, other members of this family seem to have evolved the capacity to sense danger signals perhaps independently of a microbial trigger. This is illustrated by the discovery that Nalp3 and Nalp1 are specifically activated by low concentrations of intracellular potassium. The fact that several stimuli, including bacterial toxins and some viruses, but also sterile crystals made of uric acid, asbestos or aluminium hydroxide, can trigger the Nalp3 inflammasome illustrate the fascinating prospect that microbial infections and certain danger signals may be perceived similarly by host recognition systems. Gaining insight into the function of NLR proteins in general will impact considerably on our understanding of the mechanisms underlying immunity to infection, adjuvanticity and auto-inflammatory disorders. In this review, we summarize the current knowledge on the microbial- and danger-derived signals that activate NLRs.

References

Dec 4, 2001·Current Opinion in Microbiology·W Vollmer, J V Höltje
Feb 14, 2002·The Journal of Biological Chemistry·Ramunas M VabulasHermann Wagner
Mar 26, 2002·Trends in Microbiology·Stephen E GirardinDana J Philpott
Jan 16, 2003·Current Biology : CB·Edward K WrightWilliam F Dietrich
Aug 20, 2003·Cellular Microbiology·Mathias ChamaillardDana J Philpott
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Roberto BruzzoneHannah Monyer
Jun 11, 2004·Nature·Sanjeev MariathasanVishva M Dixit
Jun 24, 2004·European Journal of Immunology·Stephen E Girardin, Dana J Philpott
Feb 8, 2005·Current Opinion in Microbiology·Ivo G Boneca
Feb 19, 2005·Human Molecular Genetics·Pirro HysiWilliam O C Cookson
Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Stephan WeidingerThomas Illig
Jan 13, 2006·Nature·Thirumala-Devi KannegantiGabriel Núñez
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
Jan 24, 2006·Nature Genetics·Eric D Boyden, William F Dietrich
Mar 11, 2006·Cell Death and Differentiation·C WertsD J Philpott
Jul 25, 2006·Trends in Immunology·Cosima T BaldariCesare Montecucco
Sep 21, 2006·The Journal of Biological Chemistry·Amal AmerGabriel Núñez
Sep 30, 2006·The Journal of Biological Chemistry·Thirumala-Devi KannegantiGabriel Núñez
Nov 18, 2006·Nature Immunology·Jörg H FritzStephen E Girardin
Dec 14, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J Alain KummerJürg Tschopp
Jan 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ivo G BonecaStephen E Girardin
Mar 23, 2007·Microbes and Infection·Philip RosenstielStefan Schreiber
Jun 30, 2007·Cell Death and Differentiation·V PétrilliJ Tschopp
Jul 11, 2007·Journal of Endotoxin Research·Min-Fu Tsan, Baochong Gao
Aug 11, 2007·Seminars in Immunopathology·Edward A MiaoAlan Aderem
Sep 7, 2007·Seminars in Immunopathology·Christine E Becker, Luke A J O'Neill
Oct 31, 2007·Immunity·Thirumala-Devi KannegantiGabriel Núñez
Dec 12, 2007·The Journal of Experimental Medicine·Fayyaz S SutterwalaRichard A Flavell
Dec 29, 2007·The Journal of Pathology·L A M CarneiroL H Travassos
May 14, 2008·American Journal of Respiratory Cell and Molecular Biology·Peter W SwaanDaren L Knoell

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Citations

Aug 11, 2011·Inflammatory Bowel Diseases·Ida SchoultzDerek M McKay
May 24, 2012·Biomolecular NMR Assignments·Ming-Yuan SuChi-Fon Chang
Jan 13, 2010·Immunology and Cell Biology·Katarzyna BulekXiaoxia Li
Jun 2, 2009·Nature Reviews. Drug Discovery·Kaoru GeddesStephen E Girardin
Jul 3, 2009·The Journal of Biological Chemistry·Jooeun LeeStephen E Girardin
Nov 8, 2012·Current Opinion in Gastroenterology·Susan J Robertson, Stephen E Girardin
Mar 15, 2012·Pancreas·Rafaz HoqueWajahat Z Mehal
Jun 23, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Z TiszlaviczY Mándi
May 2, 2012·Infection and Immunity·Balamayooran TheivanthiranSamithamby Jeyaseelan
Aug 21, 2009·Journal of Cell Science·Damien ArnoultStephen E Girardin
May 26, 2012·PLoS Neglected Tropical Diseases·Edith A Fernández-FigueroaIngeborg Becker
Mar 3, 2010·PLoS Pathogens·Andreas J MüllerWolf-Dietrich Hardt
Nov 6, 2009·Biomolecular NMR Assignments·Anderson de Sa PinheiroWolfgang Peti
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Charles MaisonneuveEnnio De Gregorio
Jan 12, 2011·Annual Review of Immunology·Jean-Laurent CasanovaLluis Quintana-Murci
Jul 30, 2014·The American Journal of Gastroenterology·Serena MagniDonatella Barisani
Apr 29, 2010·Current Rheumatology Reports·Johannes NowatzkySvetlana Krasnokutsky
Feb 12, 2013·Developmental and Comparative Immunology·Jiaren ZhangZhanjiang Liu
Oct 6, 2010·Developmental and Comparative Immunology·Virginie Cuvillier-HotAurélie Tasiemski
Nov 26, 2015·The International Journal of Biochemistry & Cell Biology·Tao XuJun Li
Nov 26, 2009·The Journal of Allergy and Clinical Immunology·Stuart E Turvey, David H Broide
Sep 17, 2009·Immunological Reviews·Russell D Salter, Simon C Watkins
Jul 10, 2013·Cellular Microbiology·Jessica TsalikisStephen E Girardin
Aug 14, 2012·Scandinavian Journal of Immunology·R El Ridi, H Tallima
Jun 21, 2011·Immunological Reviews·Michael MinnicozziMatthew J Fenton
Jul 30, 2011·EMBO Reports·Damien ArnoultStephen E Girardin
Apr 5, 2014·Journal of Molecular Recognition : JMR·Jitendra MaharanaSukanta Kumar Pradhan
Jun 18, 2015·Journal of Neurochemistry·Péter NagyősziIstván A Krizbai

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