The microbial content of non-sterile pharmaceuticals distributed in Norway

The Journal of Hospital Infection
C Charnock

Abstract

Seventy-seven registered trademark pharmaceuticals and allied products, not required by the relevant monographs to comply with the test for sterility, were investigated for their microbial content. All the products examined complied with current regulations with respect to the numbers and types of microbes isolated, indicating the effectiveness of existing production practices in meeting existing standards. Gram-positive endospore-forming rods accounted for the majority of the bacteria isolated. Gram-negative rods were present for the most part in incidental numbers. However, some of these were of species that have been previously indicated as opportunistic pathogens and which should be considered as objectionable in pharmaceuticals. A number of the isolates showed antibiotic resistances unusual for the species in question.

References

Jan 1, 1991·The Journal of Hospital Infection·S Lacey, S V Want
May 1, 1988·Antimicrobial Agents and Chemotherapy·D J WeberC A Thomann
May 1, 1986·The Journal of Applied Bacteriology·B Holmes
Apr 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P R HsuehK T Luh

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Citations

Jul 31, 2009·Journal of Clinical Microbiology·Vincent C C ChengK Y Yuen
Jun 25, 2015·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·M RatajczakJ Długaszewska
Dec 22, 2005·The Annals of Pharmacotherapy·Paul F LongIan Chi-Kei Wong
Sep 30, 2021·Journal of Applied Microbiology·Charlène BermondValérie Poulet

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