The microbial environment and its influence on asthma prevention in early life

The Journal of Allergy and Clinical Immunology
E von Mutius

Abstract

There is accumulating evidence to suggest that the environmental microbiome plays a significant role in asthma development. The very low prevalence of asthma in populations highly exposed to microbial environments (farm children and Amish populations) highlights its preventive potential. This microbial diversity might be necessary to instruct a well-adapted immune response and regulated inflammatory responses to other inhaled and ingested environmental elements, such as allergens, particles, and viruses. Like the internal gut microbiome, which is increasingly recognized as an important instructor of immune maturation, the external environmental microbiome might shape immune responses on the skin, airway mucosal surfaces, and potentially also the gut early in life. The diversity of the external microbial world will ensure that of the many maladapted pathways leading to asthma development, most, if not all, will be counterbalanced. Likewise, important contributors to asthma, such as allergen sensitization and allergic manifestations early in life, are being suppressed. Thus the facets of innate immunity targeted by microbes and their compounds and metabolites might be the master switch to asthma and allergy protection, which has ...Continue Reading

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C R Woese, G E Fox
Feb 16, 1999·Lancet·U KrämerH E Wichmann
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O S Von EhrensteinR von Kries
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J RiedlerM Schreuer
Feb 2, 2000·Applied and Environmental Microbiology·I M WoutersD J Heederik
Aug 24, 2000·The New England Journal of Medicine·T M BallA L Wright
May 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S H DownsJ K Peat
Aug 23, 2002·JAMA : the Journal of the American Medical Association·Dennis R OwnbyEdward L Peterson
Aug 23, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F HorakT Frischer
Sep 20, 2002·The New England Journal of Medicine·Charlotte Braun-FahrländerUNKNOWN Allergy and Endotoxin Study Team
Oct 7, 2003·Annual Review of Microbiology·Michael S Rappé, Stephen J Giovannoni
Mar 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M WaserUNKNOWN ALEX Study Team
May 8, 2004·The Journal of Allergy and Clinical Immunology·Robert Theodoor van StrienUNKNOWN ALEX Study Team
Aug 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K RadonD Nowak
Oct 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D Schram-BijkerkUNKNOWN PARSIFAL Study Group
Oct 27, 2005·Diabetes·Katja RadonUNKNOWN Chronic Autoimmune Disease and Contact to Animals (CAT) Study Group
Feb 17, 2006·The European Respiratory Journal·C ZekveldP Cullinan
Apr 25, 2006·The Journal of Allergy and Clinical Immunology·Markus Johannes EgeUNKNOWN Parsifal Study team
May 6, 2006·The Journal of Allergy and Clinical Immunology·Bianca SchaubErika von Mutius
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Michael R Perkin, David P Strachan
Oct 13, 2006·Environmental Health Perspectives·Carolyn M KercsmarTerry Allan
Feb 15, 2007·Allergy·A ViinanenE O Terho
Mar 14, 2007·The Journal of Allergy and Clinical Immunology·Markus Johannes EgeUNKNOWN PARSIFAL Study team
Apr 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M WaserUNKNOWN PARSIFAL Study team
May 8, 2007·The Journal of Allergy and Clinical Immunology·Jennifer DebarryHolger Heine
May 18, 2007·The Journal of Allergy and Clinical Immunology·Juan C CeledónDiane R Gold
Aug 3, 2007·Pediatrics·Katja RadonUNKNOWN Chronische Autoimmunerkrankungen und Kontakt zu Tieren (Chronic Autoimmune Disease and Animal Contact) Study Group
Oct 12, 2007·The New England Journal of Medicine·Hans BisgaardChristian Bressen Pipper
Nov 6, 2007·International Journal of Hygiene and Environmental Health·Chih-Mei ChenJoachim Heinrich
Nov 9, 2007·Seminars in Immunopathology·Kevin Tse, Anthony A Horner
Jun 24, 2008·Immunology and Allergy Clinics of North America·Erika von Mutius, Katja Radon
Apr 8, 2009·The Journal of Allergy and Clinical Immunology·Bianca SchaubErika von Mutius
Nov 7, 2009·Science·Elizabeth K CostelloRob Knight
Dec 9, 2009·The Journal of Allergy and Clinical Immunology·Petra Ina PfefferleUNKNOWN PASTURE Study Group
Jan 7, 2010·PloS One·Markus HiltyWilliam O C Cookson
Feb 16, 2010·Applied and Environmental Microbiology·Raina M MaierAnne L Wright
Jul 14, 2010·The Journal of Allergy and Clinical Immunology·Marcus PetersAlbrecht Bufe

❮ Previous
Next ❯

Citations

May 20, 2016·Carbohydrate Research·Katarzyna A DudaOtto Holst
Feb 27, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Marion Kauth, Holger Heine
Oct 30, 2016·Current Opinion in Immunology·Hermelijn H SmitsPieter S Hiemstra
Aug 9, 2016·Expert Review of Clinical Immunology·Nsangou Ghogomu, Robert Kern
Oct 23, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A ForsbergM C Jenmalm
Dec 29, 2016·Current Opinion in Allergy and Clinical Immunology·Halie M Anderson, Daniel J Jackson
Jan 13, 2017·Current Opinion in Allergy and Clinical Immunology·K A Lee-SarwarA A Litonjua
May 10, 2017·Nature Reviews. Immunology·Jeremy M KinderSing Sing Way
Jun 29, 2017·Immunological Reviews·Clare M Lloyd, Sejal Saglani
Jun 21, 2017·The Journal of Allergy and Clinical Immunology·Remo FreiUNKNOWN Protection Against Allergy Study in Rural Environments (PASTURE)/Mechanisms of Early Protective Exposures on Allergy Develop
Mar 3, 2018·Environmental Health Insights·Tim Kelley, Gregory D Kearney
Feb 16, 2018·Mediators of Inflammation·Sébastien BoutinAlexander H Dalpke
Nov 9, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N O JõgiR J Bertelsen
Jan 12, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Gyaviira NkurunungiAlison M Elliott
Jun 24, 2017·The European Respiratory Journal·Christina TischerPayam Dadvand
Feb 14, 2018·The European Respiratory Journal·Juha PekkanenAnne Hyvärinen
Apr 11, 2018·Nature Medicine·Jack A GilbertRob Knight
Jul 20, 2019·Clinical Reviews in Allergy & Immunology·Charles Barnes
Nov 2, 2019·Expert Review of Clinical Immunology·Cancan QiGerard H Koppelman
Nov 30, 2019·Immunology·Nicholas A Scott, Elizabeth R Mann
Mar 7, 2020·The European Respiratory Journal·Elise M A SlobAnke H Maitland-van der Zee
Apr 10, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Mirjana TurkaljAdnan Custovic
Jul 2, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Jing LiuYanlei Li
Oct 10, 2018·Seminars in Immunopathology·Dimitra E Zazara, Petra Clara Arck
Jan 9, 2019·Frontiers in Immunology·Matthew Lacorcia, Clarissa U Prazeres da Costa
Nov 20, 2019·Journal of Clinical Medicine·Konstantinos LoverdosNikoletta Rovina
Nov 24, 2019·Scientific Reports·Lidia CasasJoachim Heinrich
May 4, 2017·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Irina Lehmann
May 24, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Clemens Heuson, Claudia Traidl-Hoffmann
Feb 26, 2019·Statistical Methods in Medical Research·Rosa ArborettiLuigi Salmaso
Mar 23, 2019·Frontiers in Cellular and Infection Microbiology·Ian A Myles
Oct 18, 2019·The European Respiratory Journal·Howard H F TangMichael Inouye
Sep 6, 2020·International Journal of Molecular Sciences·James F Read, Anthony Bosco
Jun 17, 2020·Journal of Developmental Origins of Health and Disease·Delicia Shu-Qin OoiEvelyn Xiu-Ling Loo
Mar 25, 2017·Italian Journal of Pediatrics·Renato CutreraMarzia Duse
Nov 9, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carla MastrorilliKarin Hoffmann-Sommergruber
Apr 16, 2019·Current Epidemiology Reports·Fu-Ying Tian, Carmen J Marsit

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2021 Meta ULC. All rights reserved