The Microbiological Memory, an Epigenetic Regulator Governing the Balance Between Good Health and Metabolic Disorders

Frontiers in Microbiology
Christian A Devaux, Didier Raoult

Abstract

If the transmission of biological information from one generation to the next is based on DNA, most heritable phenotypic traits such as chronic metabolic diseases, are not linked to genetic variation in DNA sequences. Non-genetic heritability might have several causes including epigenetic, parental effect, adaptive social learning, and influence of the ecological environment. Distinguishing among these causes is crucial to resolve major phenotypic enigmas. Strong evidence indicates that changes in DNA expression through various epigenetic mechanisms can be linked to parent-offspring resemblance in terms of sensitivity to metabolic diseases. Among non-genetic heritable traits, early nutrition could account for a long term deviant programming of genes expression responsible for metabolic diseases in adulthood. Nutrition could shape an inadequate gut microbiota (dysbiosis), triggering epigenetic deregulation of transcription which can be observed in chronic metabolic diseases. We review herein the evidence that dysbiosis might be a major cause of heritable epigenetic patterns found to be associated with metabolic diseases. By taking into account the recent advances on the gut microbiome, we have aggregated together different obser...Continue Reading

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Citations

Apr 27, 2019·Future Microbiology·Amadou TogoMatthieu Million
May 28, 2019·Immunology and Cell Biology·Kathy D McCoyMarkus B Geuking
Aug 29, 2020·Applied Microbiology and Biotechnology·Cigdem Celiker, Rasime Kalkan
Dec 13, 2019·Frontiers in Public Health·Christian A DevauxDidier Raoult
Feb 6, 2020·Frontiers in Genetics·Manvi SharmaTrygve O Tollefsbol
Oct 4, 2020·Annals of the New York Academy of Sciences·Catherine TamaletPhilippe Colson
Nov 3, 2020·Frontiers in Immunology·Trim LajqiHannes Hudalla
Mar 9, 2021·Frontiers in Medicine·Christian A DevauxDidier Raoult
Apr 17, 2021·Environmental Science and Pollution Research International·Amr El-SayedMohamed Kamel
Jul 18, 2021·Seminars in Cancer Biology·Faizan Haider KhanAta Abbas

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Methods Mentioned

BETA
histone acetylation
nuclear translocation

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