The microbiology of infected and noninfected leg ulcers

International Journal of Dermatology
Philip G Bowler, B J Davies

Abstract

A clinical study was undertaken to investigate and compare specifically the aerobic and anaerobic microbiology of infected and noninfected leg ulcers. Leg ulcers, defined as being infected on the basis of clinical signs, were swab sampled and investigated for aerobic and anaerobic microorganisms using stringent isolation and identification techniques. Two hundred and twenty isolates were cultured from 44 infected leg ulcers, in comparison with 110 isolates from 30 noninfected leg ulcers. Statistical analysis indicated a significantly greater mean number of anaerobic bacteria per infected ulcer (particularly Peptostreptococcus spp. and Prevotella spp.) in comparison with the noninfected ulcer group (2.5 vs. 1.3, respectively) (P < 0.05). Also, anaerobes represented 49% of the total microbial composition in infected leg ulcers compared with 36% in noninfected leg ulcers. The mean numbers of aerobes per wound in the two ulcer groups were not statistically different (P > 0.05). The study failed to demonstrate a clear correlation between commonly implicated facultative pathogens and wound infection. The isolation rate of Pseudomonas aeruginosa was generally low and, although Staphylococcus aureus was a frequent isolate in both wound...Continue Reading

References

Dec 17, 1977·Lancet·H R InghamA A Codd
Jan 1, 1992·The Australasian Journal of Dermatology·A R HalbertA Jopp-McKay
Sep 1, 1991·International Journal of Dermatology·P Gamborg Nielsen
Mar 1, 1990·The British Journal of Surgery·D Kingston, D V Seal
Sep 1, 1989·The British Journal of Dermatology·B Gilchrist, C Reed
Sep 1, 1988·The Journal of Infection·S A AdemiluyiO Akinyanju
Mar 1, 1988·Annals of the Royal College of Surgeons of England·E L GillilandJ D Lewis
May 1, 1986·Infection and Immunity·A S McKeeP D Marsh
Mar 1, 1985·Reviews of Infectious Diseases·O D RotsteinR L Simmons
Jul 1, 1974·Archives of Internal Medicine·S L Gorbach, H Thadepalli
Jan 1, 1984·Scandinavian Journal of Infectious Diseases·G ErikssonL O Kallings
Oct 1, 1984·Journal of the American Geriatrics Society·E E Pierleoni
Nov 1, 1983·Journal of the American Geriatrics Society·I H Gomolin, J L Brandt
Mar 1, 1984·Reviews of Infectious Diseases·T Hofstad
Jul 1, 1981·Journal of Clinical Pathology·D C DaltreyJ G Chattwood
Oct 25, 1982·Archives of Internal Medicine·S M Finegold
Jun 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D N Gerding
Jun 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S JohnsonD N Gerding
May 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G A BottaG Trani
May 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S M Finegold
Mar 1, 1993·FEMS Immunology and Medical Microbiology·S M FinegoldM Marina
Dec 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S M MadsenV T Rosdahl

Citations

Mar 25, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·D Dill-Müller, W Tilgen
Nov 25, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·V GentiliD Di Luca
Jan 27, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D WildeboerR G Price
Apr 13, 2005·The Journal of Hospital Infection·S L PercivalD Russell
Oct 27, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·G PellizzerF de Lalla
Mar 19, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Charlotte E DaviesD W Thomas
Jul 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth A GriceJulia A Segre
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D T WilliamsKeith G Harding
Feb 15, 2014·Advances in Wound Care·Ge ZhaoJohn E Olerud
Apr 10, 2010·The Journal of Antimicrobial Chemotherapy·K E HillDavid W Thomas
Jul 21, 2011·Journal of Biochemistry·Mika Shirasu, Kazushige Touhara
May 2, 2002·Home Healthcare Nurse·L G Ovington
May 2, 2002·Home Healthcare Nurse·L G Ovington
Apr 9, 2001·Clinical Microbiology Reviews·Philip G BowlerD G Armstrong
Jul 5, 2007·Journal of Clinical Microbiology·Diane M CitronMurray A Abramson
May 23, 2006·Journal of Clinical Pathology·W S A SmellieP J Carey
Jan 30, 2007·Journal of Clinical Pathology·W S A SmellieC A M McNulty
Mar 20, 2009·Canadian Journal of Microbiology·Karen FreemanC A Cochrane
Apr 11, 2012·International Journal of Molecular Sciences·Daniel D RhoadsS E Dowd
Dec 24, 2013·International Journal of Pharmaceutics·Serban BertesteanuRaluca Grigore
Jul 6, 2014·Journal of Pharmaceutical Sciences·Naeema MayetViness Pillay
Aug 30, 2014·International Journal of Surgery·Edi MatteraAntonello Accurso
Jan 28, 2016·Diabetes/metabolism Research and Reviews·E J G Peters
Jul 11, 2001·Mayo Clinic Proceedings·W Srikureja, P Y Takahashi
Jun 19, 2010·Journal of Dermatological Science·Brita S PukstadTerje Espevik
May 26, 2009·The Surgical Clinics of North America·Jaymie Panuncialman, Vincent Falanga
Apr 14, 2009·Veterinary Microbiology·E J WoodsS L Percival
Jul 25, 2009·The Journal of Investigative Dermatology·Jo M MartinG S Lazarus
Oct 23, 2008·International Journal of Pharmaceutics·C CanalA Ricard
Jan 29, 2008·Journal of the American Academy of Dermatology·Margaret A FonderAdam J Mamelak
Oct 31, 2007·Clinics in Plastic Surgery·Jaymie Panuncialman, Vincent Falanga
Aug 31, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·R S Howell-JonesDavid W Thomas
Mar 27, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Daniel N FrankJonathan D Trent
Sep 21, 2006·International Wound Journal·Kristine GjødsbølK A Krogfelt
Jul 27, 2007·International Wound Journal·Keith MooreKeith G Harding
Oct 9, 2012·The Journal of Pathology·Brittan S Scales, Gary B Huffnagle
May 25, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alexis N ThomasArdeshir Bayat
Nov 10, 2011·International Wound Journal·Kristine GjødsbølK A Krogfelt
May 9, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ge ZhaoJohn E Olerud
Oct 16, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·R D WolcottJennifer S White
Jun 27, 2009·Journal of Medical Microbiology·Geraint B RogersKenneth D Bruce
Jan 2, 2009·Microbiology·Christofer KarlssonInga-Maria Frick
Jan 20, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Georg DaeschleinMichael Jünger
Apr 2, 2014·Anaerobe·Elizabeth Carmel MurphyInga-Maria Frick
May 20, 2015·Diabetes & Metabolic Syndrome·Saba NoorJamal Ahmad
Oct 4, 2012·FEMS Microbiology Reviews·Elizabeth Carmel Murphy, Inga-Maria Frick
Nov 17, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J H MelendezJ M Zenilman
Nov 28, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ivan B WallDavid W Thomas
Dec 2, 2016·Journal of Medical Microbiology·Kavitha ShettigarThokur Sreepathy Murali
Nov 18, 2005·Lancet·Peter R CavanaghGeorgeanne Botek
Mar 9, 2010·The International Journal of Lower Extremity Wounds·Thanh DinhAristidis Veves
Oct 1, 2013·Journal of Cutaneous Medicine and Surgery·R Gary SibbaldPersaud Reneeka
Apr 1, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Marieke HaalboomJob van der Palen
Apr 14, 2016·Journal of Wound Care·L R Copeland-HalperinR Miraliakbari
Feb 1, 2011·Journal of Wound Care·S E DowdC E Jones
Jul 14, 2018·Annals of the New York Academy of Sciences·Lindsay R Kalan, Meghan B Brennan
Jul 18, 2018·Journal of Wound Care·Reza GhotaslouNaser Alizadeh
Aug 9, 2013·Journal of Clinical Microbiology·Isabelle FromantinVéronique Larreta Garde
Sep 9, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·S Subbu LakshmiB Suresh
Apr 28, 2006·Advances in Skin & Wound Care·Cynthia A Fleck
Nov 5, 2008·Advances in Skin & Wound Care·Stephan J Landis
Dec 1, 2007·Microbiology·Christofer KarlssonInga-Maria Frick
May 15, 2007·Current Opinion in Infectious Diseases·Terence J Ryan
Mar 23, 2019·Biomedical Materials·Wei QuWei Zhang
Jan 14, 2003·Annals of Medicine·Philip G Bowler
Jan 15, 2005·The Journal of Antimicrobial Chemotherapy·R S Howell-JonesD W Thomas
Mar 17, 2020·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Joseph J StoffelBrittany Hadj Romdhane
Oct 30, 2009·Journal of Wound Care·R D WolcottS E Dowd
Aug 25, 2016·Plastic and Reconstructive Surgery·Linsey E LindleyMarjana Tomic-Canic
Nov 23, 2005·British Journal of Nursing : BJN·Caroline Graham
Aug 30, 2008·Journal of Wound Care·R S Howell-JonesHPA GP Microbiology Laboratory Use Group
Apr 16, 2014·Advances in Skin & Wound Care·Jéssica Molina de SouzaLuciana Patricia Fernandes Abbade
Mar 31, 2016·Journal of Applied Microbiology·Adel AbouhmadRajni Hatti-Kaul
Nov 4, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Cornelia WiegandGary W Gibbons
Jul 4, 2003·Journal of Wound Care·A B G LansdownM Qvist Jensen
Jan 26, 2021·Indian Journal of Dermatology·Falguni NagAbhishek De

Related Concepts

Bacteriocidal Agents
Bacteria, Aerobic
Bacteria, Anaerobic
Bacterial Infections
Chronic Disease
Leg Ulcer
Bacteriocin Typing
Spearman Rank Correlation Coefficient

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.