The Microbiome-Mitochondrion Connection: Common Ancestries, Common Mechanisms, Common Goals

MSystems
Alfredo Franco-Obregón, Jack A Gilbert

Abstract

Lynn Margulis in the 1960s elegantly proposed a shared phylogenetic history between bacteria and mitochondria; this relationship has since become a cornerstone of modern cellular biology. Yet, an interesting facet of the interaction between the microbiome and mitochondria has been mostly ignored, that of the systems biology relationship that underpins host health and longevity. The mitochondria are descendants of primordial aerobic pleomorphic bacteria (likely genus Rickettsia) that entered (literally and functionally) into a mutualistic partnership with ancient anaerobic microbes (likely Archaea). A stable symbiosis was established, given the metabolic versatility of the early mitochondria, which were capable of providing energy with or without oxygen, whereas nutrient gathering was the assumed responsibility of the host. While microbial relationships with single-cell protists must have occurred in the past, as they occur today, the evolution of multicellular organisms generated a new framework for symbiosis with the microbial world, taking the ancient partnership to an entirely new level. Cell-cell communication between microbes and single-cell protists was augmented through multicellularity to allow distant communication bet...Continue Reading

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Citations

Sep 6, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael J HoughtonGary Williamson
Jan 30, 2020·Genome Research·Robert H MillsDavid J Gonzalez
Jul 20, 2019·Oxidative Medicine and Cellular Longevity·Jesus R HuertasSara Cogliati
Aug 2, 2018·Frontiers in Cardiovascular Medicine·Baiba Vilne, Heribert Schunkert
Feb 5, 2021·Frontiers in Nutrition·Juan Carlos BórquezRoberto Bravo-Sagua
Apr 4, 2021·Journal of Clinical Medicine·Jorge OjedaPía M Vidal
Apr 22, 2021·International Journal of General Medicine·Jiaxi ZhaoXiaofeng Yu
May 26, 2021·Trends in Molecular Medicine·Davide D'AmicoJohan Auwerx
Oct 27, 2021·Critical Reviews in Food Science and Nutrition·Min ZhouXi Ma

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